Results 61 to 70 of about 24,501 (174)

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Inhibition of LRRK2 kinase activity stimulates macroautophagy. [PDF]

, 2013
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic contributors to Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, including macroautophagy. To test whether LRRK2 has a role in regulating autophagy,
Abeti, Rosella, Manzoni, C, Lewis, Patrick A, Tooze, S, Soutar, Marc P.M., Giunti, Paola, Dihanich, Sybille, Mamais, A, Lewis, Patrick A., Plun-Favreau, H, Tooze, Sharon A, Lewis, PA, Manzoni, Claudia, Mamais, Adamantios, Bandopadhyay, Rina, Plun-Favreau, Helene, Bandopadhyay, R, Tooze, Sharon A., Dihanich, S, Soutar, MP, Giunti, P, Abeti, R, Soutar, Marc P. M.   +22 more
core   +1 more source

Global Proximity Interactome of the Human Macroautophagy Pathway

, 2021
Macroautophagy is a highly conserved eukaryotic cellular pathway involving the engulfment of macromolecules, organelles, and invading microbes by a double-membrane compartment and subsequent lysosomal degradation.
Tu, Yi Xin (Iris), Dyer, Diana, Tu, Yi Xin Iris, Vernon, Robert M., Coyaud, Etienne, Coyaud, Etienne-Marie, Kim, Peter K., St-Germain, Jonathan, St-Germain, Jonathan R., Raught, Brian, Laurent, Estelle M. N., Ridgway, Neale D., Sydor, Andrew M., Mellouk, Nora, Forman-Kay, Julie D., Laurent, Estelle, Zhao, Kexin, Li, Taoyingnan, Hua, Rong, Brumell, John H.   +19 more
core   +1 more source

Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging

Cells, 2020
Cardiovascular disease (CVD) is the number one cause of death in the United States. Advancing age is a primary risk factor for developing CVD. Estimates indicate that 20% of the US population will be ≥65 years old by 2030.
Rajeshwary Ghosh, Vishaka Vinod, J. David Symons, Sihem Boudina   +3 more
doaj   +1 more source

Brassinin Inhibits Cell Survival and Autophagy via Modulation of ROS Production and the AMPKα‐beclin1 Signaling Pathway in Gliomas

Phytotherapy Research, EarlyView.
Brassinin, a phytoalexin derived primarily from Chinese cabbage, exhibits potent anticancer activity against glioblastoma (GBM). Mechanistically, brassinin treatment elevates intracellular ROS levels in GBM cells, triggering two parallel outcomes: (i) direct induction of apoptosis, and (ii) suppression of cytoprotective autophagy through downregulation
Sunil Rauniyar, Yuhui Wang, Qiaoshan Zhang, Shicheng Zhang, Jiale Yin, Tong Zhang, Shangfeng Gao, Rutong Yu   +7 more
wiley   +1 more source

E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway

Molecules, 2018
Genetic studies have revealed that rare mutations and multiplications of the gene locus in α-synuclein (α-syn) are implicated in the pathogenesis of Parkinson’s disease (PD).
Jia-qing Yan, Yu-he Yuan, Shi-feng Chu, Guo-hui Li, Nai-hong Chen   +4 more
doaj   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Pbs2 regulates late‐stage macroautophagy in Saccharomyces cerevisiae

Animal Models and Experimental Medicine
Autophagy is crucial for maintaining cellular homeostasis and is linked to various diseases. In Saccharomyces cerevisiae, the Polymyxin B Sensitivity 2 (Pbs2) protein is a member of the mitogen‐activated protein kinase (MAPK) family and plays a role in ...
Jianing Song, Haolin Zhang, Xingyu Cao, Zizhang Ren, Chao Tian, Miao Jia, Meiling Wu, Xiaoli Wang, Juan Wang   +8 more
doaj   +1 more source

Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Autophagy Reports, 2022
The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation.
Elizabeth A. Novak, Heather L. Mentrup, Nazih Bizri, Anna E. Ramos, Kevin P. Mollen, Sidrah Khan   +5 more
doaj   +1 more source

Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants

Allergy, EarlyView.
This study shows that SDS and CAPB directly impair esophageal epithelial barrier integrity in primary EoE‐derived models. SDS induces stronger inflammatory, oxidative stress, and keratinization responses than CAPB. Both surfactants promote epithelial remodeling and partial epithelial‐mesenchymal transition (EMT), with CAPB showing a distinct ...
Ozge Ardicli, Duygu Yazici, Huseyn Babayev, Yagiz Pat, Manal Bel Imam, Hang Du, Hassan Melhem, Carina Beha, Laura Buergi, Anja Heider, Juan‐Felipe López, Sena Ardicli, Can Zeyneloğlu, Andrea Kreienbühl, Nino Stocker, Patrick Westermann, Christoph B. Messner, Mübeccel Akdis, Jan Hendrik Niess, Alain Schoepfer, Luc Biedermann, Cezmi A. Akdis, Swiss EoE Cohort Study Group, Patrick Aepli, Luc Biedermann, Ruggero Biral, Carine Blanchard, Lorenzo Botteselle, Simon Buetikofer, Emanuel Burri, Joachim Diebold, Annika Eckhold, Annett Franke, Michèle Frei, Thomas Greuter, Chantal Hasler, Wolfram Jochum, Tanja Kilchmann, Seraina Koller, Andrea Kreienbühl, Fritz Murray, Peter Netzer, Gabrielle Reichhart, Elodie Ristorcelli, Gerhard Rogler, Jean‐Benoit Rossel, Ekaterina Safroneeva, Catherine Saner, Christoph Schlag, Jon‐Duri Senn, Alain Schoepfer, Philipp Schreiner, Christine Sempoux, Dagmar Simon, Hans‐Uwe Simon, Alex Straumann, Sven Trelle, Achim Weber, Niels Willi, Marcel Zwahlen, Willem van de Veen   +60 more
wiley   +1 more source