Results 81 to 90 of about 24,501 (174)
Muscle wasting in cancer cachexia: Mechanisms and the role of exercise
Experimental Physiology, EarlyView.Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento +2 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Despite converging epidemiological evidence for the inverse relationship of regular caffeine consumption and risk of developing Parkinson's disease (PD) with animal studies demonstrating protective effect of caffeine in various neurotoxin models of PD ...
Yanan Luan +14 more
doaj +1 more source
Glia, Volume 74, Issue 11, November 2026.ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley +1 more source
Three-Dimensional Ultrastructure of Arabidopsis Cotyledons Infected with Colletotrichum higginsianum
Molecular Plant-Microbe InteractionsWe used serial block-face scanning electron microscopy (SBF-SEM) to study the host–pathogen interface between Arabidopsis cotyledons and the hemibiotrophic fungus Colletotrichum higginsianum.
Kamesh C. Regmi +6 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan +6 more
wiley +1 more source
Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation
, 2021 Autophagy is the highly conserved catabolic process, which enables the survival of a cell under unfavorable environmental conditions. In a constantly changing environment, cells must be capable of dynamically oscillating between anabolism and catabolism ...
Kurrle, Nina Susanne +3 more
core
Antigen processing for MHC presentation via macroautophagy
, 2012 Macroautophagy has recently emerged as an important catabolic process involved not only in innate immunity but also in adaptive immunity. Initially described to deliver intracellular antigens to MHC class II loading compartments, its molecular machinery ...
Christian Münz +8 more
core +1 more source
Macroautophagy regulates CD4+ T cell function
, 2011 Protein turnover is imperative for the diminution and removal of accumulated damaged proteins in the cell. Turnover is also essential to facilitate recycling of amino acids for new protein synthesis and to allow for the modification of protein levels in ...
Hubbard, Vanessa M.
core
Autophagy ReportsMacroautophagy/Autophagy is a highly conserved mechanism that targets cytoplasmic cargo for degradation and recycling. At present, 45 autophagy-related (ATG) genes have been identified in fungi.
Tabassum Ahmad Tasmi +4 more
doaj +1 more source