Results 101 to 110 of about 24,501 (174)

Editorial: Defective macroautophagy in organelle turnover: From basic mechanisms to human disease

Frontiers in Cell and Developmental Biology, 2022
Eloy Bejarano, José Antonio Rodríguez-Navarro, José Antonio Rodríguez-Navarro, Roberta Filograna, Javier Calvo-Garrido   +4 more
doaj   +1 more source

Macroautophagy and protein aggregate formation in lysosomal disease

, 2013
Lysosomal diseases comprise a group of nearly 60 distinct disorders characterized by dysfunction of the lysosomal system. While most of these disorders present with systemic involvement, nearly two-thirds are associated with severe CNS impairment.
Micsenyi, Matthew C.
core  

Effects of Autophagy Inhibition by SAR405, a Selective VPS34 Inhibitor, on Pleural Mesothelioma Cells

Thoracic Cancer
Background Pleural mesothelioma is a highly aggressive malignancy with a poor prognosis due to the limited efficacy of currently available therapies. Macroautophagy (hereafter “autophagy”) is a lysosome‐mediated degradation pathway involved in cellular ...
Yoshiki Kuwabara, Kosuke Sakai, Kota Shiraishi, Itsuka Matsumoto, Shigeru Ishii, Shin Yokosuka, Masatoshi Abe, Tomoyuki Takahashi, Yuichiro Kawano, Hiroaki Nishimura, Maiko Toda‐Sasaki, Yumiko Kobayashi‐Ogawa, Satoshi Kikuchi, Yusuke Hirata, Hiroyuki Kyoyama, Gaku Moriyama, Nobuyuki Koyama, Kazutsugu Uematsu   +17 more
doaj   +1 more source

Antiretroviral Drugs Impact Autophagy Differently in Primary Human Astrocytes

Cells
While antiretroviral therapy (ART) has significantly improved the morbidity of HIV infection, ART may contribute to the pathogenesis of HIV associated neurocognitive impairment (HIV-NCI) by interfering with autophagic processes in astrocytes.
Laura Cheney, Grace McDermott, Hillary Guzik, Joan W. Berman   +3 more
doaj   +1 more source

Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

Hepatic Medicine: Evidence and Research, 2016
Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1 1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, LA, USA ...
Dash S, Chava S, Chandra PK, Aydin Y, Balart LA, Wu T   +5 more
doaj  

A Role for PICALM in Macroautophagy and Cellular Cholesterol Homeostasis

, 2015
The dissertation will focus on deciphering novel roles for PICALM in cellular biology. PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid Protein) is a ubiquitously expressed protein that was initially identified as a partner for AF10 in a ...
Mercer, Jacob Leib
core   +1 more source

The role of E3 ubiquitin ligases in selective types of macroautophagy. [PDF]

EMBO Rep
Müller M, Winklhofer KF, Reggiori F.
europepmc   +1 more source

Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research. [PDF]

Aging Med (Milton)
Fang EF, Nilsen H, Scheibye-Knudsen M, Bohr VA, Kang L.   +4 more
europepmc   +1 more source

Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes. [PDF]

Cell Rep
Wang R, Fortier TM, Sun X, Chai F, Velentzas PD, Baehrecke EH.   +5 more
europepmc   +1 more source

Research progress on the α-synuclein-lysosome axis in Parkinson's disease: molecular mechanisms of protein aggregation, autophagy dysfunction, and therapeutic targeting. [PDF]

Front Neurosci
Fu J, Zhu C, Fan Z.
europepmc   +1 more source