Post-transplant anti-thymocyte globulin exposure predicts graft-versus-host disease and donor chimerism outcomes in reduced intensity conditioning allogeneic stem cell transplantation [PDF]
Frontiers in ImmunologyAlthough anti-thymocyte globulin (ATG) is commonly used as prophylaxis against graft-versus-host disease (GVHD) following allogeneic haematopoietic stem cell transplantation (alloSCT), there is considerable inter-patient variability in ATG exposure.
Ray Mun Koo +14 more
doaj +2 more sources
Immune reconstitution and infections with ATG versus post-transplant cyclophosphamide as GvHD prophylaxis after nonmyeloablative matched unrelated donor hematopoietic stem cell transplantation [PDF]
Frontiers in ImmunologyIntroductionAnti-thymocyte globulin (ATG) and post-transplantation cyclophosphamide (PTCy) are both used as in-vivo lymphodepleting treatment in allogeneic hematopoietic stem cell transplantation (HSCT), particularly in the matched unrelated donor (MUD ...
Mesire Aydin +20 more
doaj +2 more sources
Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin
Frontiers in ImmunologyBackgroundAnti-Thymocyte Globulin (ATG) is commonly used to prevent graft-versus-host disease (GVHD), but the optimal dosage and type of ATG remains to be determined.ObjectiveWe compared retrospectively the safety and efficacy outcomes of allogeneic ...
Polina Stepensky +2 more
exaly +3 more sources
Anti-human T lymphocyte porcine immunoglobulin attenuates experimental autoimmune encephalomyelitis by inhibiting T cell activation [PDF]
Scientific ReportsAnti-human T lymphocyte porcine immunoglobulin (P-ATG) is a type of anti-thymocyte globulin (ATG) drug that has been used as an immunosuppressant for severe aplastic anemia and graft-versus-host disease for decades.
Junchen Liu +21 more
doaj +2 more sources
Comparable outcomes with anti-thymocyte globulins versus basiliximab in kidney transplantation from controlled circulatory death donors [PDF]
Transplant InternationalDue to organ shortage, donation after circulatory death (DCD) has increased. As DCD kidney grafts have higher rates of delayed graft function (DGF), the French national protocol mandates the use of hypothermic machine perfusion and routine anti-thymocyte
Martin Deslais +36 more
doaj +2 more sources
Assessment of the duration of lymphocyte depletion after anti-thymocyte globulin for rejection in lung transplant recipients [PDF]
JHLT OpenOptimal strategies to detect response to rejection treatment with anti-thymocyte globulin (ATG) in lung transplant recipients (LTR) are poorly defined. We hypothesized that LTR with stable or improving lung function after ATG [“functional responders” (FR)
Thomas J. Wert +5 more
doaj +2 more sources
Инфекция и иммунитет, 2023 T-cell immune response is extremely important in protecting human body from diverse viral infections. It is known that it can ensure viral clearance and complete recovery in patients with humoral immunodeficiency.
Vladimir V. Kopat +8 more
doaj +1 more source
Evaluating Autophagy in Preimplantation Embryos
Autophagy Reports, 2022 Autophagy is an essential cellular degradation pathway in the mammalian preimplantation embryo. In this review, the process of autophagy is outlined and its function pertaining to preimplantation embryos is discussed.
Zuleika C. L. Leung +4 more
doaj +1 more source
Hematology/Oncology and Stem Cell Therapy, 2020 Antithymocyte globulin (ATG) is a widely accepted part of the conditioning regimen applied in the setting of hematopoietic stem cell transplantation (HSCT) to prevent graft rejection and graft-versus-host disease.
Lisa V.E. Oostenbrink +11 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundAnti-thymocyte globulin (ATG) prophylaxis reduces graft-versus-host disease (GVHD) incidence. This meta-analysis aimed to explore the long-term efficacy of ATG and the influencing factors in patients undergoing allogeneic hematopoietic stem ...
Xue Yang +5 more
doaj +1 more source