Results 1 to 10 of about 155 (87)
Journal of Advanced Research, 2021 Introduction: Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects.
Yechun Xu, Wei Tang, Heng Li
exaly +3 more sources
Arctigenin: pharmacology, total synthesis, and progress in structure modification
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Arctium lappa L. is a prevalent medicinal herb and a health supplement that is commonly used in Asia. Over the last few decades, the bioactive component arctigenin has attracted the attention of researchers because of its anti-inflammatory, antioxidant ...
Qing-kun Shen +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2021 Arctigenin, one of the active ingredients extracted from Great Burdock (Arctium lappa) Achene, has been found to relieve myocardial infarction injury.
Cheng-Yin Liu +14 more
doaj +1 more source
Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways. [PDF]
PLoS ONE, 2014 Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated.
Teruhito Yamashita +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Fructus arctii is commonly used in Chinese medicine, and arctiin and arctigenin are its main active ingredients. Arctiin has low bioavailability in the human body and needs to be converted into arctigenin by intestinal microbes before it can be absorbed ...
Zheng Lu +13 more
doaj +1 more source
Egyptian Liver Journal, 2021 Background In spite of the huge advances in recent medicine, there is no effective drug that completely protects the liver from toxic materials. This study was conducted to investigate the hepatoprotective effect of arctigenin from burdock (Arctium lappa)
Ghalia Mohamed Kanawati +2 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Arctigenin is a phenylpropanoid dibenzylbutyro lactone lignan compound with multiple biological functions. Previous studies have shown that arctigenin have neuroprotective effects in Alzheimer’s disease (AD) models both in vivo and in vitro; however, its
Yanan Li +11 more
doaj +1 more source
Frontiers in Immunology, 2021 Multiple sclerosis (MS) is a chronic disease in the central nervous system (CNS), characterized by inflammatory cells that invade into the brain and the spinal cord.
Liangpeng Wei +10 more
doaj +1 more source
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer. [PDF]
PLoS ONE, 2018 Arctigenin is evaluated for antitumor efficacy in patients with pancreatic cancer. It has an inhibitory activity on mitochondrial complex I.Therefore, plasma lactate level of patients after arctigenin administration was evaluated for biomarker of ...
Rumi Fujioka +9 more
doaj +1 more source
Frontiers in Immunology, 2021 The RNA-binding protein tristetraprolin (TTP) is an anti-inflammatory factor that prompts the mRNA decay of target mRNAs and is involved in inflammatory diseases such as rheumatoid arthritis (RA).
Linxi lv +17 more
doaj +1 more source