ARC‐18 Improved Motor Performance Through Inhibiting ACLY‐Mediated Smad2/3 Acetylation in a Model of Duchenne Muscular Dystrophy [PDF]
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.ABSTRACT Background Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle weakness, with inflammation and fibrosis contributing to its pathogenesis. Despite advancements in genetic disease‐modifying treatment, there is currently no effective pharmacological treatment for DMD.
Chongyang Chen +9 more
wiley +2 more sources
Arctigenin from Forsythia viridissima Fruit Inhibits the Replication of Human Coronavirus [PDF]
Int J Mol SciCoronavirus can cause various diseases, from mild symptoms to the recent severe COVID-19. The coronavirus RNA genome is frequently mutated due to its RNA nature, resulting in many pathogenic and drug-resistant variants.
Chansoo Kim +5 more
core +2 more sources
Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging
Journal of Nanobiotechnology, 2017 Background Tracking targets of natural products is one of the most challenging issues in fields ranging from pharmacognosy to biomedicine. It is widely recognized that the biocompatible nanoparticle (NP) could function as a “key” that opens the target ...
Qingxin Cui +13 more
doaj +2 more sources
General commentary: 28-Day oral chronic toxicity study of arctigenin in rats [PDF]
Frontiers in PharmacologyMichelle Carnazza +9 more
doaj +2 more sources
Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs
Frontiers in Pharmacology, 2019 Our previous studies have investigated the systematic pharmacokinetic characteristics, biological activities, and toxicity of arctigenin. In this research, the potential toxicities of arctigenin in beagle dogs were investigated via repeated 28-day ...
Jie Li +28 more
doaj +1 more source
Enzyme-hydrolyzed Fruit of : A Rich Source of (-)-(8,8′)-Arctigenin
Natural Product Communications, 2016 In Jurinea mollis fruit, the dibenzylbutyrolactone-type lignan glycoside arctiin and its aglycone arctigenin were determined for the first time using a combination of optimized enzymatic treatment and complementary spectrometric (HPLC-MS, GC-MS) and ...
Rita Könye +10 more
doaj +1 more source
Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors [PDF]
, 2016 Lignans are biologically active phenolic compounds related to lignin, produced in different plants. Arctigenin, a dibenzylbutyrolactone-type lignan, has been used as a neuroprotective agent for the treatment of encephalitis.
Borbély, S +9 more
core +1 more source
Pharmacokinetics of Arctigenin and Fructus Arctii Powder in Piglets
Frontiers in Veterinary Science, 2019 Fructus arctii, also known as great power seed, is the dried fruit of Arctium lappa of the family Compositae. It is a commonly used veterinary herbal medicine, and arctigenin is the main active ingredient.
Bin He +10 more
doaj +1 more source
Antioxidants, 2022 Major obstacles in current breast cancer treatment efficacy include the ability of breast cancer cells to develop resistance to chemotherapeutic drugs and the off-target cytotoxicity of these drugs on normal cells, leading to debilitating side effects ...
Caroline Schuster +3 more
doaj +1 more source
Effect of arctigenin on osteoclast-like cell function.
, 2014 (A) Effects of arctigenin on the pit-forming activity of osteoclast-like cells cultured on dentin slices. Osteoclast-like cell preparations were cultured on dentin slices in the presence or absence of 1 µM arctigenin. After cultivation for 48 h, cells on
Shigetoshi Kadota (510441) +7 more
core +1 more source