Results 11 to 20 of about 1,749 (159)
RETRACTED: Arctigenin inhibits the progression of colorectal cancer through epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway. [PDF]
PLoS ONEBackgroundColorectal cancer (CRC) is a significant disease worldwide, with high mortality rates. Conventional treatment methods often lead to metastasis and drug resistance, highlighting the need to explore new drugs and their potential molecular ...
Xiang-Fan Chen +6 more
doaj +3 more sources
Frontiers in Pharmacology, 2018 Burdock (Arctium lappa) is a popular vegetable in China and Japan that is consumed for its general health benefits. The principal active component of burdock is arctigenin, which shows a range of bioactivities in vivo and in vitro.
Ying Sun +24 more
doaj +2 more sources
Cellular Physiology and Biochemistry, 2013 Background/Aims: Arctigenin possesses biological activities, but its underlying mechanisms at the cellular and ion channel levels are not completely understood.
Zhenying Zhao +6 more
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Identification of Antileukemic Compound From Ginger by Integrating UHPLC–MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro and In Vivo Experimental Validation [PDF]
Food Science &Nutrition, Volume 14, Issue 9, September 2026.Metabolomic screening and UHPLC–MS verification identified Arctigenin as a candidate antileukemic compound from ginger. Multi‐dimensional computational and experimental validation demonstrated its anti‐AML activity through apoptosis induction and tumor growth suppression, with potential involvement of PARP1 and NFκB1.
Mengjun Huang +9 more
wiley +2 more sources
Tumor Biology, 2017 Gallbladder cancer has poor prognosis and limited therapeutic options. Arctigenin, a representative dibenzylbutyrolactone lignan, occurs in a variety of plants.
Mingdi Zhang +11 more
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Arctigenin efficiently enhanced sedentary mice treadmill endurance.
PLoS ONE, 2011 Physical inactivity is considered as one of the potential risk factors for the development of type 2 diabetes and other metabolic diseases, while endurance exercise training could enhance fat oxidation that is associated with insulin sensitivity ...
Xuan Tang +6 more
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Arctigenin as a promising anticancer agent: a comprehensive review of molecular mechanisms across major carcinomas [PDF]
Frontiers in PharmacologyDespite the presence of numerous efficacious bioactive compounds, the development of effective cancer therapies remains necessary. Thus, the exploitation of the medicinal potential of bioactive compounds in cancer management has become an urgent demand ...
Deena Elsori +9 more
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Arctigenin inhibits prostate tumor cell growth in vitro and in vivo [PDF]
Clinical Nutrition Experimental, 2017 The low bioavailability of most phytochemicals limits their translation to humans. We investigated whether arctigenin, a novel anti-inflammatory lignan from the seeds of Arctium lappa, has favorable bioavailability/potency against prostate cancer.
Piwen Wang +5 more
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28-Day Oral Chronic Toxicity Study of Arctigenin in Rats [PDF]
Frontiers in Pharmacology, 2018 Arctium lappa (burdock) is the most popular daily edible vegetable in China and Japan because of its general health tonic effects. Previous studies focused on the beneficial role of Arctigenin but neglected its potential side-effects and toxicities.
Yu-jun Tan +33 more
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Toxicology Reports, 2022 Dibenzylbutyrolactone-type lignans are phenolic compounds of medical importance. The purpose of the study was to determine the effects of two such lignans, arctigenin and trachelogenin on the motility of isolated rat ileum and obtain indications on their
Peter Kiplang’at Koech +3 more
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