Results 1 to 10 of about 1,095 (112)

Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells [PDF]

Marine Drugs, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and exhibits a devastating 5-year survival rate. The most recent procedure for the treatment of PDAC is a combination of several conventional chemotherapeutic agents ...
Gwonhwa Song, Woonghee Lee
exaly   +4 more sources

Isolation and Identification of Allelopathic Substances from Forsythia suspensa Leaves, and Their Metabolism and Activity [PDF]

Plants
The fruit of Forsythia suspensa (Thunb.) Vahl has been used in traditional Chinese medicine as “Forsythiae fructus”. The species is also grown in parks and gardens, and on streets and building lots, as an ornamental plant, but it requires pruning.
Hisashi Kato-Noguchi, Yuga Takahashi, Shunya Tojo, Toshiaki Teruya   +3 more
doaj   +2 more sources

Dietary (Poly)phenol Intake, Inflammatory Biomarkers, and Mild Cognitive Impairment in Italian Adults [PDF]

Antioxidants
Background: Dietary (poly)phenols have been proposed to protect against age-related cognitive decline through antioxidant, anti-inflammatory, and neuroprotective mechanisms.
Margherita Grasso, Francesca L’Episcopo, Giuseppe Toscano, Evelyn Frias-Toral, Stefano Muratore, Maria Angela Tripodi, Sabrina Musso, Veronica Bentivegna, Lucrezia Costanzo, Giusi Fatati, Chiara Mascali, Giorgia Serena Gullotta, Raynier Zambrano-Villacres, Lisandra León Brizuela, Fabio Galvano, Giuseppe Grosso, Justyna Godos, Raffaele Ferri, Giuseppe Lanza, Filippo Caraci   +19 more
doaj   +2 more sources

Construction of lignan glycosides biosynthetic network in Escherichia coli using mutltienzyme modules [PDF]

Microbial Cell Factories
Background Due to the complexity of the metabolic pathway network of active ingredients, precise targeted synthesis of any active ingredient on a synthetic network is a huge challenge.
Yuqi Qiao, Doudou Huang, Yajing Li, Songfan Jiang, Xiao Chen, Junfeng Chen, Ying Xiao, Wansheng Chen   +7 more
doaj   +2 more sources

Analysis of Softwood Lignans by Comprehensive Two-Dimensional Liquid Chromatography [PDF]

Molecules, 2023
Lignans constitute a large group of phenolic plant secondary metabolites possessing high bioactivity. Their accurate determination in plant extracts with a complex chemical composition is challenging and requires advanced separation techniques.
Danil I. Falev, Ilya S. Voronov, Alexandra A. Onuchina, Anna V. Faleva, Nikolay V. Ul’yanovskii, Dmitry S. Kosyakov   +5 more
doaj   +2 more sources

Lignans Associated Differences in Salt Stress Responses of Flax (Linum usitatissimum L.) Genotypes In Vitro [PDF]

Cells
The objective of this study was to investigate the association between lignan content and stress responses in flax genotypes with contrasting lignan levels.
Moumita Roy Chowdhury, Katarína Ražná, Jindra Valentová, Emil Švajdlenka, Eva Ivanišová, Anirban Jyoti Debnath, Jit Mukherjee, Veronika Štefúnová, Mizgin Mehmet, Paračková Patrícia, Marián Miko   +10 more
doaj   +2 more sources

Optimal extraction conditions and quantification of lignan phytoestrogens in cereal grains using targeted LC-MS/MS [PDF]

Frontiers in Nutrition
Lignans are phytoestrogens found in various forms such as glycosides, ester-linked oligomers, and aglycones in a variety of foods, including soy products, legumes, grains, nuts, vegetables, and fruits.
Yoonjeong Kim, Heon-Woong Kim, Jeehye Sung, Younghwa Kim, Younghwa Kim   +4 more
doaj   +2 more sources

Identification and investigation of a novel NADP+-dependent secoisolariciresinol dehydrogenase from Isatis indigotica

Frontiers in Plant Science, 2022
Cofactors are crucial for the biosynthesis of natural compounds, and cofactor engineering is a useful strategy for enzyme optimization due to its potential to enhance enzyme efficiency.
Xiaoyi Shi, Xiaoyi Shi, Jiaran Geng, Jingxian Feng, Yingbo Yang, Yingbo Yang, Xueqi Ma, Wansheng Chen, Wansheng Chen, Ying Xiao   +9 more
doaj   +1 more source

Study of lignans in wine originating from different types of oak barrels

OENO One, 2023
This study aimed to determine the concentrations of the lignans pinoresinol, secoisolariciresinol, matairesinol and isolariciresinol in white wines aged in twelve different oak barrels originating from different cooperages and regions and with different ...
Milos Vidlar, Katerina Dadakova, Tomas Kasparovsky, Mojmir Baron, Božena Průšová, Jiri Sochor   +5 more
doaj   +1 more source

Synthesis of (−)−deoxypodophyllotoxin and (−)−epipodophyllotoxin via a multi-enzyme cascade in E. coli

Microbial Cell Factories, 2021
Background The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years, the commercial demand for this compound rose notably because of the high clinical
Davide Decembrino, Alessandra Raffaele, Ronja Knöfel, Marco Girhard, Vlada B. Urlacher   +4 more
doaj   +1 more source