Results 1 to 10 of about 2,580 (116)

Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation [PDF]

Frontiers in Immunology
BackgroundCartilage injury is a hallmark of osteoarthritis (OA). erb-B2 receptor tyrosine kinase 2 (ERBB2) has been reported to be involved in mediating the therapeutic effects of polyphenols in orthopedic diseases.
Haibei Hu, Gaoshan Li, Yangxu Wang, Suyu Xie, Feng Cao, Huanyu Li, Xubin Gao   +6 more
doaj   +2 more sources

The Metabolic Diversity of Different Salsola Species Valorized Through Untargeted Metabolomics and In Vitro Bioassays: The Importance of Phenolic Constituents [PDF]

Plants
Five Salsola species have been studied as sources of bioactive compounds using a comprehensive, untargeted metabolomic and bioactivity assessment. Plant material was extracted using ethyl acetate (EA), water, and methanol (MeOH). S.
Hajar Salehi, Marco Armando De Gregorio, Gokhan Zengin, Sakina Yagi, Gunes Ak, Enver Saka, Fevzi Elbasan, Evren Yildiztugay, Leilei Zhang, Stefano Dall’Acqua, Luigi Lucini   +10 more
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Molecular Mechanisms of Lignans in Lowering Blood Pressure and Anti-Obesity Effects: A Review [PDF]

Foods
Lignans are naturally occurring compounds found in a wide variety of plant species, including flaxseed, soybean, pumpkin seed, broccoli, sesame seed, and some berries.
Gitishree Das, Sandra Gonçalves, José Basilio Heredia, Nayely Leyva-López, Anabela Romano, Spiros Paramithiotis, Han-Seung Shin, Jayanta Kumar Patra   +7 more
doaj   +2 more sources

Construction of lignan glycosides biosynthetic network in Escherichia coli using mutltienzyme modules [PDF]

Microbial Cell Factories
Background Due to the complexity of the metabolic pathway network of active ingredients, precise targeted synthesis of any active ingredient on a synthetic network is a huge challenge.
Yuqi Qiao, Doudou Huang, Yajing Li, Songfan Jiang, Xiao Chen, Junfeng Chen, Ying Xiao, Wansheng Chen   +7 more
doaj   +2 more sources

Identification of the Microbial Transformation Products of Secoisolariciresinol Using an Untargeted Metabolomics Approach and Evaluation of the Osteogenic Activities of the Metabolites

Molecules, 2023
Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent
Wen-Xuan Yu, Hok-Him Tang, Jun-Jie Ye, Hui-Hui Xiao, Chung-Yan Lam, Tim-Fat Shum, Zhi-Kang Sun, Yuan-Zhen Li, Xin-Yu Zang, Wen-Chao Du, Jian-Ping Zhang, Tsz-Hung Kong, Li-Ping Zhou, Jia-Chi Chiou, Chun-Fai Kung, Kam-Wah Mok, Jing Hu, Man-Sau Wong   +17 more
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GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea

Molecules, 2022
Medicinal plants are widely used in folk medicine to treat various diseases. Thonningia sanguinea Vahl is widespread in African traditional medicine, and exhibits antioxidant, antibacterial, antiviral, and anticancer activities. T.
Sameh S. Elhady, Elsayed A. Ibrahim, Marwa S. Goda, Mohamed S. Nafie, Hanan Samir, Reem M. Diri, Abdulrahman M. Alahdal, Ama Kyeraa Thomford, Alaa El Gindy, Ghada M. Hadad, Jihan M. Badr, Reda F. A. Abdelhameed   +11 more
doaj   +1 more source

NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax

Molecules, 2021
Lignans, phenolic plant secondary metabolites, are derived from the phenylpropanoid biosynthetic pathway. Although, being investigated for their health benefits in terms of antioxidant, antitumor, anti-inflammatory and antiviral properties, the role of ...
Kamar Hamade, Ophélie Fliniaux, Jean-Xavier Fontaine, Roland Molinié, Elvis Otogo Nnang, Solène Bassard, Stéphanie Guénin, Laurent Gutierrez, Eric Lainé, Christophe Hano, Serge Pilard, Akram Hijazi, Assem El Kak, François Mesnard   +13 more
doaj   +1 more source

Biological functions of lignans in plants

Agriculture, 2021
Naturally occurring lignans are present in seeds, nuts, cereals, vegetables, and fruits. Lignans play various roles in plants and their multipurpose functions of different organisms including humans is considerable.
Ražná Katarína, Nôžková Janka, Vargaová Angéla, Harenčár Ľubomír, Bjelková Marie   +4 more
doaj   +1 more source

Study of lignans in wine originating from different types of oak barrels

OENO One, 2023
This study aimed to determine the concentrations of the lignans pinoresinol, secoisolariciresinol, matairesinol and isolariciresinol in white wines aged in twelve different oak barrels originating from different cooperages and regions and with different ...
Milos Vidlar, Katerina Dadakova, Tomas Kasparovsky, Mojmir Baron, Božena Průšová, Jiri Sochor   +5 more
doaj   +1 more source

Identification and investigation of a novel NADP+-dependent secoisolariciresinol dehydrogenase from Isatis indigotica

Frontiers in Plant Science, 2022
Cofactors are crucial for the biosynthesis of natural compounds, and cofactor engineering is a useful strategy for enzyme optimization due to its potential to enhance enzyme efficiency.
Xiaoyi Shi, Xiaoyi Shi, Jiaran Geng, Jingxian Feng, Yingbo Yang, Yingbo Yang, Xueqi Ma, Wansheng Chen, Wansheng Chen, Ying Xiao   +9 more
doaj   +1 more source