Neuroprotective effects of arctigenin on cerebral ischemia-reperfusion injury in rats via the EPO/EPOR-JAK2-STAT5 signaling pathway [PDF]
Frontiers in PharmacologyIntroductionCerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process with significant morbidity and mortality, and there is no specific agent.
Shanshan Xu +8 more
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RETRACTION: Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage‐Induced Vasospasm through PI3K/Akt Pathway in a Rat Model [PDF]
Biomed Res IntBioMed Research International, Volume 2026, Issue 1, 2026.
BioMed Research International
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Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact? [PDF]
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær +4 more
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Arctigenin Attenuates Hepatic Stellate Cell Activation via Endoplasmic Reticulum-Associated Degradation (ERAD)-Mediated Restoration of Lipid Homeostasis [PDF]
J Agric Food ChemArctigenin, a natural lignan from Arctium lappa L., exhibits potent antifibrotic activity, yet its molecular mechanisms remain unclear. Endoplasmic reticulum (ER) stress is known to promote hepatic stellate cell (HSC) activation and liver fibrosis.
Li, Yakun; id_orcid +8 more
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Arctigenin-Enriched Burdock Seed Oil (ABSO): A New Skin Brightening Botanical Extract
Cosmetics, 2023 The Arctium lappa L. plant, commonly known as burdock, has been used therapeutically for hundreds of years. Arctigenin (ATG) is an active ingredient in burdock, albeit at low quantities or mostly in the form of acrtiin (arctigenin-4-glucoside).
Tsuyoshi Ishii +6 more
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Oxygen Tolerance Domestication of Blautia sp. AUH-JLD56 Enables Efficient Aerobic Bioconversion of Arctigenin to 3′-Demethylarctigenin [PDF]
MicroorganismsAnaerobic bacteria are the dominant group in the animal intestinal microbiota, and most strains cannot grow normally upon exposure to air. Blautia sp.
Wenya You +5 more
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Determination of Arctiin and Arctigenin Contents in Arctium Tomentosum Mill. by HPLC Method [PDF]
E-Journal of Chemistry, 2011 A simple, precise, rapid and accurate, binary-phase high performance liquid chromatographic method has been developed for the determination of arctiin and arctigenin contents in the Arctium tomentosumMill. with short run time.
Xiaoying Zhou +4 more
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Immunopharmacological potential of Arctium lappa L. in immune-mediated skin diseases: A critical review of experimental and clinical evidence [PDF]
Frontiers in PharmacologyBackgroundArctium lappa L. (A. lappa) has been used in traditional medicine worldwide and is increasingly being investigated for its immunomodulatory and anti-inflammatory effects.
Mengyao Yang +16 more
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Ligand Binding Affinities of Arctigenin and Its Demethylated Metabolites to Estrogen Receptor Alpha
Molecules, 2013 Phytoestrogens are defined as plant-derived compounds with estrogen-like activities according to their chemical structures and activities. Plant lignans are generally categorized as phytoestrogens.
Masao Hattori +2 more
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Quercetin–Arctigenin Co-Treatment Induces Mitochondrial Dysfunction and Apoptotic Cell Death Through Metabolic Stress in Malignant Mesothelioma Cells [PDF]
LifeMalignant mesothelioma is an aggressive cancer with limited therapeutic options, highlighting the need for novel strategies targeting metabolic vulnerabilities.
Moon-Kyun Cho +3 more
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