Results 71 to 80 of about 24,501 (174)

Chapter 5 Measuring Macroautophagy in S. cerevisiae: Autophagic Body Accumulation and Total Protein Turnover

, 2008
Macroautophagy has been implicated in various physiological functions and severe human diseases. Accordingly, there is a high interest in determining macroautophagy both qualitatively and quantitatively.
Tanja Prick, Michael Thumm, Thumm, Michael, Prick, Tanja   +3 more
core   +1 more source

Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches

Frontiers in Cellular Neuroscience
Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein.
Saman Rashid, Maria Dimitriadi
doaj   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Monitoring Antigen Processing for MHC Presentation via Macroautophagy [PDF]

, 2019
Macroautophagy has recently emerged as an important catabolic process involved not only in innate immunity but also in adaptive immunity. Initially described to deliver intracellular antigens to MHC class II loading compartments, its molecular machinery ...
da Silva, Rosa Barreira, Christian Münz, Monique Gannage, Gannage, M., Munz, C., da Silva, R. B., Gannage, Monique, Münz, Christian, Rosa Barreira da Silva   +8 more
core   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

TNF-{alpha} induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells [PDF]

, 2011
Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II molecules.
Fokken, Claudia, Luenemann, Anna, Turville, S G, Jan D. Lünemann, Christian Münz, Stuart G. Turville, Christian W. Keller, Anna Lünemann, Lünemann, J D, Schmidt, Jens, Jens Schmidt, Keller, Christian W., Keller, C W, Lünemann, A, Münz, Christian, Fokken, C, Turville, Stuart G., Claudia Fokken, Schmidt, J, Luenemann, Jan D., Münz, C   +20 more
core   +1 more source

Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy

, 2022
Macroautophagy is a “cell cleansing” process that rids cells of protein aggregates and damaged organelles that may contribute to disease pathogenesis and the dysfunctions associated with aging.
Mark F. McCarty
core   +1 more source

Melanoma LAMP-2C Modulates Tumor Growth and Autophagy

Frontiers in Cell and Developmental Biology, 2018
Autophagy plays critical but diverse roles in cellular quality control and homeostasis potentially checking tumor development by removing mutated or damaged macromolecules, while conversely fostering tumor survival by supplying essential nutrients during
Liliana Pérez, Anthony L. Sinn, George E. Sandusky, Karen E. Pollok, Karen E. Pollok, Karen E. Pollok, Janice S. Blum   +6 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source