Results 31 to 40 of about 24,501 (174)
Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases
Molecules, 2015 Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav +2 more
doaj +1 more source
Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation
, 2010 Macroautophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a key role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins, and regulating protein levels in ...
Rut Valdor +11 more
core +1 more source
Frontiers in Immunology, 2015 Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since MHC class II molecules are loaded with lysosomal products for CD4+ T cell stimulation, macroautophagy supports intracellular antigen processing onto MHC class II molecules.
Christian eMuenz
doaj +1 more source
Macroautophagy in immunity and tolerance
, 2009 Autophagy and proteasomal degradation constitute the two main catabolic pathways in cells. While the proteasome degrades primarily short-lived soluble proteins, macroautophagy, the main constitutive autophagic pathway, delivers cell organelles and ...
Monique Gannagé +5 more
core +1 more source
Macroautophagy, alpha-synuclein and dopamine neurotransmission: implications for Parkinson’s disease [PDF]
, 2018 Parkinson’s disease (PD) is an incurable neurological disease characterised by impairment of motor function, death of substantia nigra pars compacta (SNc) dopamine (DA) neurons and accumulation of the protein α-synuclein.
Hunn, Benjamin Henry Mcleod
core +1 more source
Does Exercise Regulate Autophagy in Humans? A Systematic Review and Meta-Analysis
Autophagy Reports, 2023 Background Macroautophagy/autophagy is an essential recycling process that is involved in a wide range of biological functions as well as in diseases. The regulation of autophagy by exercise and the associated health benefits have been revealed by rodent
Xiang-Ke Chen +5 more
doaj +1 more source
PLoS ONE, 2021 Serum supplementation during bovine embryo culture has been demonstrated to promote cell proliferation and preimplantation embryo development. However, these desirable outcomes, have been associated with gene expression alterations of pathways involved ...
Edgar Joel Soto-Moreno +3 more
doaj +3 more sources
Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease
Frontiers in Endocrinology, 2020 Proteins to be secreted through so-called “conventional mechanisms” are characterized by the presence of an N-terminal peptide that is a leader or signal peptide, needed for access to the endoplasmic reticulum and the Golgi apparatus for further ...
Claudio Daniel Gonzalez +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Anti-tumor immunity influences cancer cell reliance upon ATG7
OncoImmunology, 2020 Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman +8 more
doaj +1 more source