Results 21 to 30 of about 24,501 (174)

Topology and Function of the S. cerevisiae Autophagy Protein Atg15

Cells, 2023
The putative phospholipase Atg15 is required for the intravacuolar lysis of autophagic bodies and MVB vesicles. Intracellular membrane lysis is a highly sophisticated mechanism that is not fully understood.
Lisa Marquardt, Marco Montino, Yvonne Mühe, Petra Schlotterhose, Michael Thumm   +4 more
doaj   +1 more source

Discovery of Atg5/Atg7-independent alternative macroautophagy [PDF]

, 2009
Macroautophagy is a process that leads to the bulk degradation of subcellular constituents by producing autophagosomes/autolysosomes(1-3). It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essential genes for mammalian macroautophagy. Here we show,
Toku Kanaseki, Fujitani, Kenji, Tsujimoto, Yoshihide, Kenji Fujitani, Masaaki Komatsu, Takeshi Mizuta, Nishida, Yuya, Mizuta, Takeshi, Yuya Nishida, Yoshihide Tsujimoto, Arakawa, Satoko, Kanaseki, Toku, Hirofumi Yamaguchi, Shigeomi Shimizu, Shimizu, Shigeomi, Kinya Otsu, Komatsu, Masaaki, Otsu, Kinya, Satoko Arakawa, Yamaguchi, Hirofumi   +19 more
core   +1 more source

Regulation of Presynaptic Neurotransmission by Macroautophagy [PDF]

, 2012
SummarymTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic plasticity, and autophagic degradation of cellular components.
Cheng, Hsiao-Chun, Yarygina, Olga, Setlik, Wanda, Kholodilov, Nikolai, Torres, Ciara A., Sulzer, David, Hernandez, Daniela, Gershon, Michael, Cebrián, Carolina, Tang, Guomei, Mosharov, Eugene V., Burke, Robert E.   +11 more
core   +1 more source

Differential Autophagy Response in Men and Women After Muscle Damage

Frontiers in Physiology, 2021
Following muscle damage, autophagy is crucial for muscle regeneration. Hormones (e.g., testosterone, cortisol) regulate this process and sex differences in autophagic flux exist in the basal state.
Hui-Ying Luk, Casey Appell, Danielle E. Levitt, Danielle E. Levitt, Nigel C. Jiwan, Jakob L. Vingren   +5 more
doaj   +1 more source

Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

Pharmaceutical Biology, 2021
Context Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and anti-aging. Objective To evaluate the effect of ICA on natural aging rat.
Jie Zheng, Shanshan Hu, Jinxin Wang, Xulan Zhang, Ding Yuan, Changcheng Zhang, Chaoqi Liu, Ting Wang, Zhiyong Zhou   +8 more
doaj   +1 more source

Molecular machinery of macroautophagy and its deregulation in diseases [PDF]

, 2011
Macroautophagy maintains cellular homeostasis through targeting cytoplasmic contents and organelles into autophagosomes for degradation. This process begins with the assembly of protein complexes on isolation membrane to initiate the formation of ...
Ip, Nancy Y., Nancy Y. Ip, Wong, ASL, Ip, NY, Wong, Alan S.L., Alan S.L. Wong, Zelda H. Cheung, Cheung, ZH, Cheung, Zelda H.   +8 more
core   +1 more source

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

Translational Neurodegeneration, 2012
Background The A53T mutation in the α-synuclein gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanced macroautophagy in patients ...
Huang Yue, Chegini Fariba, Chua Germaine, Murphy Karen, Gai Weiping, Halliday Glenda M   +5 more
doaj   +1 more source

Selective macroautophagy for immunity [PDF]

, 2010
Macroautophagy was thought to be an unspecific bulk degradation process. However, Ponpuak et al. (2010) show in this issue of Immunity that cytosolic proteins are selectively recruited to autophagosomes to become metabolized to bactericidal ...
Münz, C, Münz, Christian
core   +1 more source

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

BMC Neuroscience, 2018
Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs).
Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning, Nadia Stefanova   +5 more
doaj   +1 more source

Macroautophagy Modulates Synaptic Function in the Striatum [PDF]

, 2014
The kinase mechanistic target of rapamycin (mTOR) is a regulator of cell growth and survival, protein synthesis-dependent synaptic plasticity, and macroautophagic degradation of cellular components.
Torres, Ciara
core   +1 more source