Results 1 to 10 of about 2,768 (127)

Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation. [PDF]

Adv Sci (Weinh)
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Chen X, Gao H, Wu W, Shi P, Chen Y, Zhang A, Cheng Z, Wu W, Yu Z, Zhang Y.   +9 more
europepmc   +2 more sources

LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1. [PDF]

PLoS ONE
Chaperone-mediated autophagy (CMA) promotes cancer cell survival by selectively removing oxidatively damaged proteins, yet its precise molecular mechanisms and role in redox adaptation remain incompletely understood.
Shuangshuang Le, Tongtong Guo, Meng Yang, Tianjuan Tang, Zhijie Liu, Yang Zheng, Maogui Pang   +6 more
doaj   +2 more sources

A Lamp2a-linked RNA secreted by ADSCs prevents ENO1–lactylation–glycolysis feedback and cell malignant behavior in triple-negative breast cancer [PDF]

Cell Death and Disease
Triple-negative breast cancer (TNBC) is a subtype characterized by the absence of common BC receptors and is closely associated with a hypoxic tumor microenvironment. However, the mechanisms through which TNBCs adapt to hypoxia remain elusive. This study
Shaoqiang Cheng, Bingshu Xia, Liru Li, Shu Zhao, Qihong Zhang, Xue Hui, Xiaolei Liu, WenJing Xiong, Wanzhi Chen, Yue Zhang   +9 more
doaj   +2 more sources

Deficient chaperone-mediated autophagy in macrophages aggravates colitis and colitis-associated tumorigenesis in mice [PDF]

Molecules and Cells
Chaperone-mediated autophagy (CMA) is a highly selective form of autophagy responsible for the degradation of specific cytosolic proteins within lysosomes. Recent research has established a significant correlation between CMA and colorectal cancer (CRC).
Weichun Zhu, Zehao Chen, Yunqian Gao, Chungang Zhai, Xia Li, Ning Wang, Kang Fu, Wentao Chen, Jieqiong Peng, Dan Xu, Lei Qiao, Wenqiang Chen   +11 more
doaj   +2 more sources

HSP90AA1 Facilitates Vascular Calcification in Chronic Kidney Disease Involving Chaperone-Mediated Autophagy [PDF]

Biomedicines
Background: Chronic kidney disease (CKD) associated vascular calcification (VC) is a leading cause of cardiovascular mortality, partially driven by osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Chaperone-mediated autophagy (CMA)
Yaling Zhang, Ming Li, Yanwen Luo, Liming Huang, Sipei Chen, Guisen Li, Yi Li, Li Wang   +7 more
doaj   +2 more sources

Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy

Cells, 2021
In recent years autophagy has attracted the attention of researchers from many medical fields, including cancer research, and certain anti-macroautophagy drugs in combination with cytotoxic or targeted therapies have entered clinical trials.
Sabina Berezowska, Mario P. Tschan, Ralph A Schmid   +2 more
exaly   +3 more sources

High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model [PDF]

Frontiers in Pharmacology
Diabetic nephropathy (DN) is one of the most prevalent microvascular complications of diabetes mellitus. In the present study, the effects of PLCG1 DN, as well as its underlying molecular mechanisms associated with ferroptosis, were investigated.
Jun Ge, Zhenzhen Wang, Ting Xu, Ruifeng Jiang, Xuefeng Zhang   +4 more
doaj   +2 more sources

Chaperone mediated autophagy is deficient in spinal motoneurons of ALS patients with TDP-43 proteinopathy [PDF]

Acta Neuropathologica Communications
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective loss of motor neurons (MNs), ultimately resulting in paralysis and respiratory failure within 3 to 5 years of onset. Fewer than 10% of ALS cases
Daniel Garrigos, Marta Martinez-Morga, Ana Pombero, Raquel García-Lopez, Diego Pastor, Dolores Riquelme, Miguel Blanquer, Francisca Iniesta, Rut Valdor, Emilio Geijo-Barrientos, Gunnar Hargus, José María Moraleda, Salvador Martínez   +12 more
doaj   +2 more sources

Sufentanil attenuates LPS-induced acute lung injury by suppressing ferroptosis and maintaining GPX4 protein abundance [PDF]

Frontiers in Cell and Developmental Biology
IntroductionAcute lung injury (ALI) is a severe inflammatory syndrome characterized by disruption of the alveolar-capillary barrier, pulmonary edema, and impaired gas exchange.
Xiaoyun Guo, Weifeng Yan, Wenyong Peng, Runbin Yan   +3 more
doaj   +2 more sources

Circulating Plasma Cells as a Minimally Invasive Adjunct to Bone Marrow Aspirates for Genetic Analysis of ER Stress and Autophagy in Multiple Myeloma: A Feasibility Study [PDF]

Biomedicines
Background: Multiple myeloma (MM) is characterised by clonal expansion of plasma cells (PCs) in the bone marrow (BM). Disease assessment and monitoring typically rely on invasive, single-site procedures, such as BM biopsies (BMBs), which may inadequately
A.-M. Joëlle Marivel, Therese M. Becker, Alexander James, Yafeng Ma, Nirupama D. Verma, Tara L. Roberts, Silvia Ling   +6 more
doaj   +2 more sources