Results 11 to 20 of about 3,129 (150)

The two-domain architecture of LAMP2A within the lysosomal lumen regulates its interaction with HSPA8/Hsc70

Autophagy Reports, 2022
Chaperone-mediated autophagy (CMA) is a unique proteolytic pathway, in which cytoplasmic proteins recognized by HSPA8/Hsc70 (heat shock protein 8) are transported into lysosomes for degradation.
Yuta Ikami, Kazue Terasawa, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama   +4 more
doaj   +2 more sources

Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism

iScience
Summary: Primary biliary cholangitis is characterized by breaking of immune tolerance and disorders of bile acid metabolism. Our previous study found that abnormal expression of Lamp2 was detected in PBC patients.
Qingling Fan, Guanya Guo, Yinan Hu, Yi Lu, Rui Su, Jiaqi Yang, Erzhuo Xia, Shuoyi Ma, Miao Zhang, Jingbo Wang, Ting Li, Ying Han   +11 more
doaj   +2 more sources

Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis

Scientific Reports, 2017
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), the key protein in the chaperone-mediated autophagy (CMA) pathway, is elevated in breast tumor tissues. However, the exact effects and mechanisms of CMA
Qi Han, Youcai Deng, Sha Chen, Rui Chen, Mingzhen Yang, Zhujun Zhang, Xiongshan Sun, Wei Wang, Ying He, Fangjie Wang, Xiaodong Pan, Peng Li, Wenjing Lai, Hongqin Luo, Pei Huang, Xiao Guan, Yafei Deng, Jun Yan, Xianjie Xu, Yan Wen, An Chen, Chuanmin Hu, Xiaohui Li, Shuhui Li   +23 more
doaj   +2 more sources

The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR‐99a/mTOR‐Mediated Autophagy and Apoptosis

Advanced Science
The mammalian target of rapamycin (mTOR) is a critical signaling hub for sustaining cancer survival. Targeting mTOR and inducing autophagic cell death downstream of it represent promising therapeutic strategies for cancer prevention.
Hui‐Fang Hu, Jia‐Ying Fu, Lei Han, Gui‐Bin Gao, Wei‐Xia Zhang, Si‐Ming Yu, Nan Li, Yang‐Jia Li, Yi‐Fan Lu, Xiao‐Feng Ding, Yun‐Long Pan, Yang Wang, Qing‐Yu He   +12 more
doaj   +2 more sources

Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity [PDF]

Nature Communications
Chaperone-mediated autophagy (CMA) is a selective autophagic process essential for maintaining cellular quality and responding to stress. Dysregulation of the CMA pathway is increasingly recognized in various cancers, yet the mechanisms behind CMA ...
Yonghua Li, Min Sheng, Weijie Li, Simin Liu, Botao Wang, Bing Liu, Mei Luo, Xiao Zhou, Qiaoxi Xia, Shihong Hong, Ziyuan Zheng, Shi-Yuan Cheng, Xiaobing Jiang, Junjun Li, Tianzhi Huang   +14 more
doaj   +2 more sources

CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway [PDF]

Cell Death and Disease
Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis.
Linxi Li, Anju Zuo, Ruoyu Yin, Qiangqiang Liu, Chen Liu, Na Li, Dan Xu, Shaomeng Zhang, Jiarui Li, Shengyun Lei, Shiyan Ruan, Tingting Li, Yuan Guo   +12 more
doaj   +2 more sources

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

Nature Communications, 2017
The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylation ...
Wenming Li, Jinqiu Zhu, Juan Dou, Hua She, Kai Tao, Haidong Xu, Qian Yang, Zixu Mao   +7 more
doaj   +2 more sources

LAMP1 and LAMP2A localise to axonal organelles with distinct motility dynamics and partially overlapping molecular signatures in human neurons. [PDF]

J Cell Sci
LAMP1 and LAMP2A (an isoform of LAMP2) are abundant proteins of late endosomal/lysosomal compartments that are often used interchangeably to label what is assumed to be the same organelle population, potentially obscuring distinct physiological roles ...
Abouward R, Abdelhafid AM, Wilkins OG, Lee SY, Ibrahim F, Skehel M, Ting A, Birsa N, Ule J, Schiavo G.   +9 more
europepmc   +4 more sources

The Simultaneous Effects of Aerobic Training and Octopamine on the Mitophagy of the Brown Adipose Tissue after the Induction of Intoxication by Deeply Heated Oil in Male Wistar Rats [PDF]

Journal of Fasting and Health, 2020
Introduction: Deep heated oils produce toxins that pose significant risk to the human health. The present study aims to investigate the simultaneous effects of aerobic training and octopamine consumption on the mitophagy of the brown adipose tissue after
Sadegh Abdollahi, Khalid Mohamadzadeh Salamat, Kamal Azizbeigi, Zaher Etemad   +3 more
doaj   +1 more source

Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

Molecular Metabolism, 2023
Objective: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation.
You-Jin Choi, Sung Ho Yun, Jihyeon Yu, Yewon Mun, Wonseok Lee, Cheon Jun Park, Byung Woo Han, Byung-Hoon Lee   +7 more
doaj   +1 more source