Results 21 to 30 of about 3,129 (150)

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples [PDF]

Frontiers in Molecular Neuroscience
IntroductionAutophagy is a cellular stress response that has been shown in the literature to be active in cerebral cells after a traumatic brain injury (TBI).
Tommaso Livieri, Letizia Alfieri, Emiliana Giacomello, Djordje Alempijević, Tijana Petrovic, Yanko Georgiev Kolev, Davide Radaelli, Margherita Neri, Stefano D’Errico   +8 more
doaj   +2 more sources

Chaperone‐mediated autophagy affects tumor cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma

Thoracic Cancer, 2021
Background Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway of selective soluble proteins. Lysosomal membrane associated protein 2a (LAMP2a) is the lysosomal membrane receptor of CMA and influences CMA activity.
Dujuan Cao, Danyang Shan, Wenli Yan, Zifang Zhang, Qianqian Song, Yuanyuan Jiang, Xinmiao Zhang, Zhongxian Zhang, Zhimin Wang, Yaohe Wang, Shuangshuang Lu   +10 more
doaj   +1 more source

APOE4 dysregulates autophagy in cultured cells

Autophagy Reports, 2022
Human APOE4 (apolipoprotein E4 isoform) is a powerful genetic risk factor for late-onset Alzheimer disease (AD). Many groups have investigated the effect of APOE4 on the degradation of amyloid β (Aβ), the main component of plaques found in the brains of ...
Gianna M. Fote, Joan S. Steffan
doaj   +1 more source

Supplemental Figure 4. Lamp2a Silencing Decreased and Lamp2a Overexpression Increased Luciferase protein levels in CMA-reporter Expressing H9c2 cells.

, 2022
The Figure represents the additional immunoblot data for Fig 5. H9c2 cells with Lamp2a knock down or overexpression, were transfected with either KFERQ-luciferase (KFERQ-Luc) reporter plasmid or control Empty-luciferase (Empty-Luc) plasmid for 72 hours ...
Rajeshwary Ghosh (9764078), James Scott Pattison (9764284)   +1 more
core   +1 more source

GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis

Ecotoxicology and Environmental Safety, 2022
Exposure to antimony (Sb), recently identified as a nerve pollutant, can result in neuron damage; but, associated-neurotoxicological mechanisms were still not clear.
Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang, Xinyuan Zhao   +14 more
doaj   +1 more source

Lamp2A à la lumière de l'évolution

, 2018
Lamp2A à la lumière de l'évolution.
Guiguen, Yann, Seiliez, Iban, Lescat, Laury, Mourot, Brigitte, Herpin, Amaury, Veron, Vincent, Bobe, Julien   +6 more
core   +4 more sources

RNA-Protein Interaction Analysis of SARS-CoV-2 5′ and 3′ Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection

mSystems, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus. The viral genome is capped at the 5′ end, followed by an untranslated region (UTR). There is a poly(A) tail at the 3′ end, preceded by a UTR.
Rohit Verma, Sandhini Saha, Shiv Kumar, Shailendra Mani, Tushar Kanti Maiti, Milan Surjit   +5 more
doaj   +1 more source

Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progressionResearch in context

EBioMedicine, 2019
Background: Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME).
Ruibo Wang, Yantong Liu, Li Liu, Mei Chen, Xiuxuan Wang, Jingyun Yang, Yanqiu Gong, Bi-Sen Ding, Yuquan Wei, Xiawei Wei   +9 more
doaj   +1 more source

Chaperone Mediated Autophagy Substrates and Components in Cancer

Frontiers in Oncology, 2021
Chaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of vesicles formation.
Javiera Rios, Alvaro Sequeida, Amelina Albornoz, Amelina Albornoz, Mauricio Budini, Mauricio Budini   +5 more
doaj   +1 more source

Chaperone-mediated autophagy promotes breast cancer angiogenesis via regulation of aerobic glycolysis.

PLoS ONE, 2023
Evidence shows that chaperone-mediated autophagy (CMA) is involved in cancer cell pathogenesis and progression. However, the potential role of CMA in breast cancer angiogenesis remains unknown.
Rui Chen, Peng Li, Yan Fu, Zongyao Wu, Lijun Xu, Junhua Wang, Sha Chen, Mingzhen Yang, Bingjie Peng, Yao Yang, Hongwei Zhang, Qi Han, Shuhui Li   +12 more
doaj   +1 more source