Results 31 to 40 of about 3,129 (150)

Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway

Frontiers in Immunology, 2022
Prototheca bovis, a highly contagious pathogen, causes bovine mastitis, resulting in premature culling of affected cows and severe economic losses. Infection with P.
Wenpeng Zhao, Maolin Xu, Herman W. Barkema, Xiaochen Xie, Yushan Lin, Sohrab Khan, John P. Kastelic, Dong Wang, Zhaoju Deng, Bo Han   +9 more
doaj   +1 more source

Supplemental Figure 5. Lamp2a Alteration Did Not Affect Lysosomal Membrane protein levels.

, 2022
 Macroautophagy flux assays were performed using Lamp2a silenced and overexpressing cardiomyocytes. (A) Cardiomyocytes transfected with Lamp2a or control (Ctrl) siRNA were treated with or without Baf A1 and LAMP2a and LAMP1 protein levels determined.
Rajeshwary Ghosh (9764078), James Scott Pattison (9764284)   +1 more
core   +1 more source

Supplemental Figure 1.LAMP2a Levels were Altered with Pharmacological Agents

, 2022
(A) Rat neonatal cardiomyocytes were treated with 2 µM Geldanamycin (GA) or Veh (Vehicle: DMSO) for 24 hours and the protein levels LAMP2a, LAMP1, HSC-70, and b-actin were determined by immunoblotting; N=4/group.
Rajeshwary Ghosh (9764078), James Scott Pattison (9764284)   +1 more
core   +1 more source

Autophagic Heterogeneity in Gastric Adenocarcinoma

Frontiers in Oncology, 2021
Background and AimGastric/gastroesophageal junction (GEJ) adenocarcinoma is a heterogeneous disease, with various etiologies and with tumors encompassing a spectrum of histologic and molecular subtypes.
Ju-Yoon Yoon, Ju-Yoon Yoon, Christine Brezden-Masley, Catherine J. Streutker, Catherine J. Streutker   +4 more
doaj   +1 more source

Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells

Cells, 2020
We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann–Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the cholesterol accumulation associated with NPC1 deficiency.
Elsa Meneses-Salas, Ana García-Melero, Patricia Blanco-Muñoz, Jaimy Jose, Marie-Sophie Brenner, Albert Lu, Francesc Tebar, Thomas Grewal, Carles Rentero, Carlos Enrich   +9 more
doaj   +1 more source

Inhibition of JNK increases the sensitivity of hepatocellular carcinoma cells to lysosomotropic drugs via LAMP2A destabilization

Cell Death Discovery, 2021
Alteration of lysosomal homeostasis is common in cancer cells, which often feature an enlarged and peripheral distributed lysosomal compartment and the overexpression of cathepsins.
Enrico Desideri, Maria Rosa Ciriolo
doaj   +1 more source

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A [PDF]

, 2017
The lysosomal storage disease cystinosis, caused by cystinosin deficiency, is characterized by cell malfunction, tissue failure, and progressive renal injury despite cystine-depletion therapies. Cystinosis is associated with defects in chaperone-mediated
Xin, Qisheng, Gavathiotis, Evripidis, Jinzhong Zhang, Bucci, Cecilia, He, Jing, Jing He, Mahalakshmi Ramadass, Sergio D. Catz, Cuervo, Ana María, Evripidis Gavathiotis, Ana María Cuervo, Zhang, Jinzhong, Catz, Sergio D., Gennaro Napolitano, Kiosses, William B, Cecilia Bucci, Ramadass, Mahalakshmi, Kiosses, William B., William B. Kiosses, Stephanie Cherqui, Celine Rocca, Johnson, Jennifer L, Qisheng Xin, Rocca, Celine, Cherqui, Stephanie, Jennifer L. Johnson, Johnson, Jennifer L., Napolitano, Gennaro, Catz, Sergio D   +28 more
core   +1 more source

DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis [PDF]

, 2021
The dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis ...
Zhang, Jinzhong, Catz, Sergio D., Johnson, Jennifer L, Cherqui, Stephanie, Johnson, Jennifer L., Pestonjamasp, Kersi, He, Jing, Rahman, Farhana, Catz, Sergio D   +8 more
core   +1 more source

Radial outer retina reflectivity (RORR) sign in LAMP2‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the radial outer retina reflectivity (RORR) sign in patients carrying pathogenic variants in the X‐linked lysosome‐associated membrane protein‐2 (LAMP2) gene and to review the histologic characteristics of LAMP2 expression in the human retina.
Rachael C. Heath Jeffery, Bohdan Kousal, Ulrike Grünert, Christine A. Curcio, Svetlana Cherepanoff, Tina M. Lamey, Michel Michaelides, Chrysanthi Tsika, Isabelle Chow, Omar A. Mahroo, Seungmin Lee, Martin Meliska, Milos Kubanek, Jakub Sikora, Siying Lin, Raymond C. B. Wong, Petra Liskova, Fred K. Chen   +17 more
wiley   +1 more source

Regulation of lamp2a levels in the lysosomal membrane [PDF]

, 2000
The selective degradation of cytosolic proteins in lysosomes by chaperone-mediated autophagy depends, at least in part, on the levels of a substrate receptor at the lysosomal membrane.
A M Cuervo, J F Dice
core