Results 51 to 60 of about 3,129 (150)
Biomolecules, 2023 The purpose of this study was to compare the immunofluorescence patterns of autophagic markers: Light chain 3 beta (LC3B), Glucose regulating protein 78 (GRP78), Heat shock cognate 71 (HSC70) and Lysosomal-associated membrane protein 2A (LAMP2A) in the ...
Mirko Maglica +7 more
doaj +1 more source
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
, 2022 Neonatal cardiomyocytes were incubated in a humidified hypoxic chamber maintained at 37°C and infused with a mixture of 94% N2, 5% CO2, 1% O2 for 24 hours.
Rajeshwary Ghosh (9764078) +1 more
core +1 more source
Autophagy in MASLD: A Metabolic and Precision Medicine Perspective
Liver International, Volume 46, Issue 9, September 2026.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga +4 more
wiley +1 more source
Cell Death and Disease, 2022 Spermatogenesis is a complex biological process that produces haploid spermatozoa and requires precise regulation by many tissue-specific factors. In this study, we explored the role and mechanism of Fork head box J2 (FOXJ2, which is highly expressed in ...
Fu-Rong Bai +8 more
doaj +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
陆军军医大学学报Objective Carboplatin inhibits tumor cell proliferation by inducing DNA damage and cell cycle arrest. Whereas abnormal regulation of the cell cycle may be involved in carboplatin resistance, the underlying regulatory mechanisms remain to be further ...
Li Zhiqun, Chen Sha
doaj +1 more source
Acylglycerol Kinase Inhibition Restores Mitophagy and Alleviates Alzheimer's Disease Pathology
MedComm, Volume 7, Issue 7, July 2026.AGK (acylglycerol kinase) is abnormally upregulated in AD patients and mouse models. By stabilizing the TOM–TIM complex, this excess AGK facilitates PINK1 translocation to the IMM and prevents its OMM accumulation, leading to mitophagy impairment.
Wensheng Li +12 more
wiley +1 more source
Tumor growth of MDA-MB-436 cells with different LAMP2A expression in xenografts.
, 2023 1 × 107 shLAMP2A or Negative and LAMP2A overexpressing or Control MDA-MB-436 cells were subcutaneously injected into nude mice. The size of the tumors was monitored by the standard formula length × width × width × 0.5 (n = 5; *P P (DOC)
Yao Yang (543059) +12 more
core +1 more source
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Neurons and glia secrete and respond to numerous proteins that are released independently of the conventional ER–Golgi pathway. These unconventionally secreted proteins exert diverse pathogenic, immunomodulatory, and neuroprotective functions and are therefore implicated in multiple neurodegenerative diseases. They originate in the cytosol and exit the
Steven A. Krauklis +3 more
wiley +1 more source