Results 71 to 80 of about 3,129 (150)

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

Frontiers in Aging Neuroscience, 2017
α-Synuclein misfolding and aggregation play an important role in the pathogenesis of Parkinson’s disease (PD). Loss of function and mutation of the PARK7/DJ-1 gene cause early-onset familial PD.
Chuan-Ying Xu, Wen-Yan Kang, Yi-Meng Chen, Tian-Fang Jiang, Jia Zhang, Li-Na Zhang, Jian-Qing Ding, Jun Liu, Sheng-Di Chen, Sheng-Di Chen   +9 more
doaj   +1 more source

Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi, Fatemeh Aboutalebi, Kianoush Dormiani, Mohammad Hossein Nasr‐Esfahani   +3 more
wiley   +1 more source

Caractérisation et étude du rôle de lamp2a chez les poissons

, 2019
Chaperone-Mediated Autophagy (CMA) is a major pathway of lysosomal proteolysis recognized as a key player in the control of numerous cellular functions, and whose defects have been associated to several human pathologies, including neurodegenerative ...
Lescat, Laury
core   +1 more source

4-Methylcatechol attenuates osteoarthritis progression by preserving GPX4 stability and limiting LAMP2A-associated lysosomal degradation

Background Loss of glutathione peroxidase 4 (GPX4) and ferroptotic chondrocyte injury have been implicated in osteoarthritis (OA), but the mechanisms regulating GPX4 protein stability remain unclear.
Dailin Chen, Tiantian Tang, Kuocheng Xu, Lei Zhang, Wenqing Li, Shufeng Li, Zhendong Ying, Linson Teng   +7 more
core   +1 more source

CMA promoted VEGFA expression of breast cancer cells.

, 2023
(A) VEGFA mRNA expression level was detected by real-time PCR in breast cancer cell line MCF7 after LAMP2A knockdown or overexpression. (B) The protein expression level of VEGFA was measured by Western blotting in MCF7 cells and MDA-MB-436 cells after ...
Yao Yang (543059), Rui Chen (95310), Qi Han (499168), Hongwei Zhang (28335), Yan Fu (110146), Peng Li (69518), Zongyao Wu (14784357), Sha Chen (408501), Lijun Xu (195394), Junhua Wang (232721), Mingzhen Yang (438079), Shuhui Li (150547), Bingjie Peng (5058722)   +12 more
core   +1 more source

Supplemental Figure 2. Empirical Determination of Optimal Dose and Time of CoCl2 Treatment to Induce CMA were Assayed.

, 2022
Different doses and times of CoCl2 treatment to optimally induce LAMP2a protein levels (and thus CMA) were tested. (A) Cardiomyocytes were treated with 100 or 200 µM CoCl2 for 24 hours and LAMP2a levels were determined by immunoblots; N=4/group.
Rajeshwary Ghosh (9764078), James Scott Pattison (9764284)   +1 more
core   +1 more source

TFE3 fusion proteins promote the progression of TFE3 rearranged renal cell carcinoma via enhancing chaperone-mediated lipophagy

Cell Communication and Signaling
Background TFE3 rearranged renal cell carcinoma (TFE3 rRCC), classified as a distinct entity of RCCs, exhibits aggressive biological behavior and possesses unique metabolic characteristics.
Wenliang Ma, Yi Chen, Guijuan Chen, Lei Yang, Yanwen Lu, Xiang Dong, Dongmei Li, Weidong Gan   +7 more
doaj   +1 more source

Colocalization of p62 with LC3B and LAMP2A confirms the presence of undegraded autophagosomes and autophagolysosomes.

, 2019
(A) IF for LC3B (Green), p62 (Red) and DAPI (Blue) in a CTL (AG004392) and DS (AG006872) fibroblast cell line at basal levels or after serum starvation.
Colin C. Anderson (5132279), Kenneth N. Maclean (171227), David J. Orlicky (7853594), Kristofer S. Fritz (159782), Peter S. Harris (351495), Abhishek K. Rauniyar (3944789), David Siegel (136835), James R. Roede (180021), Stefanos Aivazidis (3944795), Abhilasha Jain (7853588), John O. Marentette (7853591)   +10 more
core   +1 more source

CMA promoted VEGFA expression through regulation of HK2-mediated aerobic glycolysis.

, 2023
(A) Lactate level was detected in TCM from MDA-MB-231 cells after LAMP2A knockdown or overexpression. (B) ECAR was detected in MDA-MB-231 cells with different LAMP2A expression, followed by injection of (vertical line) glucose (25 mM), oligomycin (1 μM),
Yao Yang (543059), Rui Chen (95310), Qi Han (499168), Hongwei Zhang (28335), Yan Fu (110146), Peng Li (69518), Zongyao Wu (14784357), Sha Chen (408501), Lijun Xu (195394), Junhua Wang (232721), Mingzhen Yang (438079), Shuhui Li (150547), Bingjie Peng (5058722)   +12 more
core   +1 more source

Chaperone-Mediated Autophagy Regulates Hypoxic Pathology in Cardiomyocytes

Autophagy Reports, 2023
Rajeshwary Ghosh, J. Scott Pattison
doaj   +1 more source