Results 81 to 90 of about 3,129 (150)

Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Clinical and Translational Medicine
Background/aims The molecular mechanisms driving nonalcoholic steatohepatitis (NASH) progression are poorly understood. This research examines the involvement of chaperone‐mediated autophagy (CMA) in NASH progression.
Shuoyi Ma, Erzhuo Xia, Miao Zhang, Yinan Hu, Siyuan Tian, Xiaohong Zheng, Bo Li, Gang Ma, Rui Su, Keshuai Sun, Qingling Fan, Fangfang Yang, Guanya Guo, Changcun Guo, Yulong Shang, Xinmin Zhou, Xia Zhou, Jingbo Wang, Ying Han   +18 more
doaj   +1 more source

Chaperone-mediated autophagy in fish: A key function amid a changing environment

Autophagy Reports
Chaperone-Mediated Autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homoeostasis and metabolism. While extensively studied in mammals, CMA’s existence in fish has only been confirmed recently, offering exciting insights ...
Simon Schnebert, Emilio J Vélez, Maxime Goguet, Karine Dias, Vincent Véron, Isabel García-Pérez, Lisa M Radler, Emilie Cardona, Stéphanie Fontagné-Dicharry, Pierre Van Delft, Franziska Dittrich-Domergue, Amélie Bernard, Florian Beaumatin, Amaury Herpin, Beth Cleveland, Iban Seiliez   +15 more
doaj   +1 more source

The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation

Ecotoxicology and Environmental Safety
Recent studies demonstrate that lipid peroxidation-induced ferroptosis participates in 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)-evoked neurotoxicity and cognitive dysfunction.
Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang   +11 more
doaj   +1 more source

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Journal of Extracellular Vesicles, 2017
Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to
Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Steven M. Pomeroy, Mohamed Badawi, Xiaohua Zhu, Ryan Pavlovicz, Ana Clara P. Azevedo-Pouly, Jeffrey Chalmers, Chenglong Li, Mitch A. Phelps, Thomas D. Schmittgen   +11 more
doaj   +1 more source

Impairment of chaperone‐mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

EMBO Molecular Medicine, 2015
Metabolite accumulation in lysosomal storage disorders (LSDs) results in impaired cell function and multi‐systemic disease. Although substrate reduction and lysosomal overload‐decreasing therapies can ameliorate disease progression, the significance of ...
Gennaro Napolitano, Jennifer L Johnson, Jing He, Celine J Rocca, Jlenia Monfregola, Kersi Pestonjamasp, Stephanie Cherqui, Sergio D Catz   +7 more
doaj   +1 more source

Characterization and study of the role of lamp2a in fish

, 2019
L’Autophagie médiée par les protéines chaperonnes (ou CMA pour Chaperone-Mediated Autophagy) est une voie majeure du catabolisme lysosomal considérée aujourd’hui comme un acteur central de contrôle de nombreuses fonctions cellulaires, et dont les défauts
Lescat, Laury
core  

The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain

, 2018
The autophagy-lysosome pathway plays a fundamental role in the clearance of aggregated proteins and protection against cellular stress and neurodegenerative conditions.
Serge Birman (302481), Bertrand Mollereau (149018), Andreas Jenny, Jun Sun (48981), Ana Mesquita (3203349), Mollereau, Bertrand, Céline Petitgas, Marion Robin (149007), Marion Robin, Jenny, Andreas, Petitgas, Céline, Mesquita, Ana, Dulac, Amina, Amina Dulac, Bertrand Mollereau, Serge Birman, Baya Chérif-Zahar, Birman, Serge, Issa, Abdul-Raouf, Sun, Jun, Andreas Jenny (411644), Céline Petitgas (5496752), Chérif-Zahar, Baya, Abdul-Raouf Issa, Amina Dulac (5496749), Abdul-Raouf Issa (3628229), Baya Chérif-Zahar (171148), Robin, Marion, Jun Sun, Ana Mesquita   +29 more
core   +1 more source

Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria

Cell Death and Disease
Conjugated fatty acids (CFAs) have been known for their anti-tumor activity. However, the mechanism of action remains unclear. Here, we identify CFAs as inducers of glutathione peroxidase 4 (GPX4) degradation through chaperone-mediated autophagy (CMA ...
Yusuke Hirata, Yuto Yamada, Soma Taguchi, Ryota Kojima, Haruka Masumoto, Shinnosuke Kimura, Takuya Niijima, Takashi Toyama, Ryoji Kise, Emiko Sato, Yasunori Uchida, Junya Ito, Kiyotaka Nakagawa, Tomohiko Taguchi, Asuka Inoue, Yoshiro Saito, Takuya Noguchi, Atsushi Matsuzawa   +17 more
doaj   +1 more source

The mechanism of LAMP2A-mediated exosome biogenesis and their role in intercellular communication

, 2023
Exosomes are a subtype of extracellular vesicles (EVs) of endocytic origin that have been the subject of intense research in the last 2 to 3 decades. Exosomes are part of a complex intercellular and inter-organ communication network, transporting and ...
M Carvalho, Catarina
core  

Effects of branched-chain amino acids on starvation-induced macroautophagy and chaperone-mediated autophagy in common carp (Cyprinus carpio)

Aquaculture Reports
Most fish experience starvation stress during overwintering, typically resulting in excessive protein degradation and muscle atrophy. Branched-chain amino acids (BCAAs), are important substrates for protein synthesis and play active roles in promoting ...
Xianglin Cao, Yi Guo, Xue Shao, Xinyu Ji, Lulu Li, Jiameng Zhou, Jianjun Chen   +6 more
doaj   +1 more source