Results 41 to 50 of about 1,561,447 (191)

Immunohistochemical Detection of the Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Formalin-Fixed and Paraffin-Embedded Tissues. [PDF]

, 2023
Autophagy is crucial for maintaining cellular homeostasis and its deregulation is involved in disease development, including cancer. The key players of chaperone-mediated autophagy (CMA), a particular selective subtype of autophagy, are HSPA8 and LAMP2A.
Berezowska, S., Tschan, M.P., Berezowska, Sabina, Galván, J.A., Losmanová, Tereza, Losmanová, T., Tschan, Mario P, Galván, José A   +7 more
core   +1 more source

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

Frontiers in Aging Neuroscience, 2019
Misfolded proteins are pathological findings in some chronic neurodegenerative disorders including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
David A. Loeffler
doaj   +1 more source

Time flies : autophagy during ageing in Drosophila [PDF]

, 2013
The process of ageing compromises the age-associated decrease in fertility, gradual loss of function, and increased vulnerability to disease, which progressively diminishes the capability of an organism to survive [1-3]. Unsurprisingly, in the past years
Nezis, I. P., Andreas Brech, Brech, Andreas, Shultz, Sebastian Wolfgang, Ioannis P., Sebastian Wolfgang   +5 more
core   +1 more source

Autophagic Heterogeneity in Gastric Adenocarcinoma

Frontiers in Oncology, 2021
Background and AimGastric/gastroesophageal junction (GEJ) adenocarcinoma is a heterogeneous disease, with various etiologies and with tumors encompassing a spectrum of histologic and molecular subtypes.
Ju-Yoon Yoon, Ju-Yoon Yoon, Christine Brezden-Masley, Catherine J. Streutker, Catherine J. Streutker   +4 more
doaj   +1 more source

Receptor proteins in selective autophagy [PDF]

, 2012
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Simone Fulda, Behrends, Christian, Christian Behrends, Fulda, Simone   +3 more
core   +1 more source

C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A

Communications Biology, 2023
C11orf54 is an ester hydrolase highly conserved across different species. C11orf54 has been identified as a biomarker protein of renal cancers, but its exact function remains poorly understood.
Junyang Tan, Wenjun Wang, Xinjie Liu, Jinhong Xu, Yaping Che, Yanyan Liu, Jiaqiao Hu, Liubing Hu, Jianshuang Li, Qinghua Zhou   +9 more
doaj   +1 more source

Diurnal Rhythms Spatially and Temporally Organize Autophagy

Cell Reports, 2019
Summary: Circadian rhythms are a hallmark of physiology, but how such daily rhythms organize cellular catabolism is poorly understood. Here, we used proteomics to map daily oscillations in autophagic flux in mouse liver and related these rhythms to ...
Mikhail Ryzhikov, Anna Ehlers, Deborah Steinberg, Wenfang Xie, Eitan Oberlander, Samuel Brown, Petra E. Gilmore, Reid R. Townsend, William S. Lane, Tamas Dolinay, Kiichi Nakahira, Augustine M.K. Choi, Jeffrey A. Haspel   +12 more
doaj   +1 more source

Chaperone-mediated autophagy: roles in neuroprotection [PDF]

Neuroscience Bulletin, 2015
Chaperone-mediated autophagy (CMA), one of the main pathways of lysosomal proteolysis, is characterized by the selective targeting and direct translocation into the lysosomal lumen of substrate proteins containing a targeting motif biochemically related to the pentapeptide KFERQ.
Zhibiao, Cai, Weijun, Zeng, Kai, Tao, Zhen, E, Bao, Wang, Qian, Yang   +5 more
openaire   +2 more sources

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Frontiers in Cell and Developmental Biology, 2020
Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity.
Erik L. Friesen, Erik L. Friesen, Yu Tong Zhang, Yu Tong Zhang, Rebecca Earnshaw, Rebecca Earnshaw, Mitch L. De Snoo, Mitch L. De Snoo, Darren M. O’Hara, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Sophie Ngana, Kevin S. Chen, Kevin S. Chen, Lorraine V. Kalia, Lorraine V. Kalia, Lorraine V. Kalia, Suneil K. Kalia, Suneil K. Kalia, Suneil K. Kalia   +21 more
doaj   +1 more source

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

Journal of Neuroinflammation, 2021
Background Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α-synuclein, chronic neuroinflammation and autophagy dysfunction.
Jialong Chen, Kanmin Mao, Honglin Yu, Yue Wen, Hua She, He Zhang, Linhua Liu, Mingque Li, Wenjun Li, Fei Zou   +9 more
doaj   +1 more source