Results 61 to 70 of about 1,561,447 (191)

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

Nature Communications, 2018
The ULK complex plays a well-known role in initiating autophagy, to recycle cellular components in response to nutritional stress. Here, the authors demonstrate a late role for ULK in auotophagosome–lysosome fusion and provide a direct link between ...
Chenyao Wang, Huafei Wang, Deyi Zhang, Wenwen Luo, Ruilong Liu, Daqian Xu, Lei Diao, Lujian Liao, Zhixue Liu   +8 more
doaj   +1 more source

Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy. [PDF]

Nat Metab
Chaperone-mediated autophagy (CMA) contributes to proteostasis maintenance by selectively degrading a subset of proteins in lysosomes. CMA declines with age in most tissues, including skeletal muscle.
Santiago-Fernández O, Coletto L, Tasset I, Kaushik S, Concepcion AR, Qaisar R, Macho-González A, Lindenau K, Diaz A, Khawaja RR, Donega S, Banskota N, Ubaida-Mohien C, Pharaoh G, Ahn B, Hartnell LM, Ramírez-Pardo I, Chavda B, Gazteluiturri A, Kinter M, Ferrucci L, Reisz JA, D'Alessandro A, Van Remmen H, Muñoz-Cánoves P, Feske S, Cuervo AM.   +26 more
europepmc   +2 more sources

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

Nature Communications, 2021
The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways ...
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo   +20 more
doaj   +1 more source

The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases

Biomedicines, 2023
Chaperone-mediated autophagy (CMA) is a process that rapidly degrades proteins labeled with KFERQ-like motifs within cells via lysosomes to terminate their cellular functioning.
Jing Liu, Lijuan Wang, Hua He, Yueying Liu, Yiqun Jiang, Jinfeng Yang   +5 more
doaj   +1 more source

Lipid excess affects chaperone-mediated autophagy in hypothalamus

, 2020
International audienceObesity is a major health problem worldwide. Overweight and obesity directly affect health-related quality of life and also have an important economic impact on healthcare systems.
Le Stunff, H., Torsoni, M. A., Portovedo, M., Reginato, A., Leal, R. F., Ignacio-Souza, L. M., Milanski, M., Hakim, M. P., Magnan, C., Torsoni, A. S., Miyamoto, J. E., Simino, L. A., Campana, M.   +12 more
core   +1 more source

Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy. [PDF]

, 2021
In recent years autophagy has attracted the attention of researchers from many medical fields, including cancer research, and certain anti-macroautophagy drugs in combination with cytotoxic or targeted therapies have entered clinical trials.
Amina Scherz, Losmanova, T., Schmid, R.A., Mario P. Tschan, Losmanová, Tereza, Scherz, Amina, Berezowska, Sabina Anna, Philipp Zens, Schmid, Ralph, Berezowska, S., Tschan, M.P., Ralph A. Schmid, Tschan, Mario P., Tereza Losmanova, Sabina Berezowska, Zens, Philipp, Scherz, A., Zens, P.   +17 more
core   +2 more sources

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide [PDF]

Autophagy, 2015
The P140 peptide, a 21-mer linear peptide (sequence 131–151) generated from the spliceosomal SNRNP70/U1–70K protein, contains a phosphoserine residue at position 140. It significantly ameliorates clinical manifestations in autoimmune patients with systemic lupus erythematosus and enhances survival in MRL/lpr lupus-prone mice.
Macri, Christophe, Wang, Fengjuan, Tasset, Inmaculada, Schall, Nicolas, Page, Nicolas, Briand, Jean-Paul, Cuervo, Ana Maria, Muller, Sylviane   +7 more
openaire   +4 more sources

Humanin is an endogenous activator of chaperone-mediated autophagy [PDF]

Journal of Cell Biology, 2017
Chaperone-mediated autophagy (CMA) serves as quality control during stress conditions through selective degradation of cytosolic proteins in lysosomes. Humanin (HN) is a mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo and in vitro. In this study, we demonstrate that HN directly activates
Zhenwei Gong, Inmaculada Tasset, Antonio Diaz, Jaime Anguiano, Emir Tas, Lingguang Cui, Regina Kuliawat, Honghai Liu, Bernhard Kühn, Ana Maria Cuervo, Radhika Muzumdar   +10 more
openaire   +2 more sources

Age-related Decline in Chaperone-mediated Autophagy [PDF]

Journal of Biological Chemistry, 2000
Intracellular protein degradation rates decrease with age in many tissues and organs. In cultured cells, chaperone-mediated autophagy, which is responsible for the selective degradation of cytosolic proteins in lysosomes, decreases with age. In this work we use lysosomes isolated from rat liver to analyze age-related changes in the levels and ...
A M, Cuervo, J F, Dice
openaire   +2 more sources

Chaperone-Mediated Autophagy in the Liver: Good or Bad?

, 2019
Hepatitis C virus (HCV) infection triggers autophagy processes, which help clear out the dysfunctional viral and cellular components that would otherwise inhibit the virus replication. Increased cellular autophagy may kill the infected cell and terminate
Krzysztof Moroz, Srikanta Dash, Yucel Aydin   +2 more
core   +1 more source