Results 81 to 90 of about 1,561,447 (191)
Cells, 2019 HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally ...
Srinivasa Reddy Bonam +2 more
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Cancer Cells Are Dependent on Chaperone-Mediated Autophagy
, 2012 Major finding: Chaperone-mediated autophagy is upregulated in tumors and promotes tumor growth. Concept: Chaperone-mediated autophagy drives metabolic alterations characteristic of malignancy.
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Chaperone-mediated autophagy in protein quality control [PDF]
Current Opinion in Cell Biology, 2011 Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with ...
Esperanza, Arias, Ana Maria, Cuervo
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Experimental Control and Characterization of Autophagy in Drosophila [PDF]
, 2008 Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology.
Thomas P. Neufeld +3 more
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Chaperone-mediated autophagy is involved in the execution of ferroptosis [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance This study reveals a common regulatory mechanism mediated by HSP90 that is shared by necroptosis and ferroptosis, two necrotic cell death mechanisms that have previously had no known mechanistic connections. Furthermore, this study demonstrates the involvement of chaperone-mediated autophagy in the execution of ...
Zheming Wu +8 more
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Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
International Journal of Cell Biology, 2012 Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors ...
Trond Lamark, Terje Johansen
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Chaperone-mediated autophagy: Advances from bench to bedside
Neurobiology of Disease, 2019 Protein homeostasis or proteostasis is critical for proper cellular function and survival. It relies on the balance between protein synthesis and degradation.
Wenming Li +5 more
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Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus [PDF]
, 2004 Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus.BackgroundIn the renal hypertrophy that occurs in diabetes mellitus, decreased proteolysis may lead to protein accumulation, but it is unclear which proteins ...
Franch, Harold A. +3 more
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The Role of Chaperone-Mediated Autophagy in Tissue Homeostasis and Disease Pathogenesis
BiomedicinesChaperone-mediated autophagy (CMA) is a selective proteolytic pathway in the lysosomes. Proteins are recognized one by one through the detection of a KFERQ motif or, at least, a KFERQ-like motif, by a heat shock cognate protein 70 (Hsc70), a molecular ...
Rut Valdor, Marta Martinez-Vicente
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Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
, 2009 Chaperone-mediated autophagy controls the degradation of selective cytosolic proteins and may protect neurons against degeneration. In a neuronal cell line, we found that chaperone-mediated autophagy regulated the activity of myocyte enhancer factor 2D ...
Gearing M +6 more
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