Results 91 to 100 of about 1,561,447 (191)
Research Advances on the Autophagy and Ferroptosis in the Development and Treatment of Lung Cancer
Chinese Journal of Lung CancerLung cancer remains a life-threatening malignancy with complex pathogenesis. This paper provides a systematic review of autophagy and ferroptosis-related signaling pathways, key regulatory factors, and their associated mechanisms, including the nuclear ...
Chengqi JIANG +6 more
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The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew +16 more
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The essential role of CCT2 in the regulation of aggrephagy
Frontiers in Aging NeuroscienceProtein aggregation, a defining characteristic of numerous human diseases, poses a significant challenge to cellular health. Autophagy, an essential cellular recycling process, specifically targets and degrades these harmful protein aggregates through a ...
Jie Luo, Ze-Sen Feng, Ji-Xin Tang
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Advance of autophagy in chronic kidney diseases
Renal Failure, 2017 Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy
Xu Deng, Yifan Xie, Aihua Zhang
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, 2017 Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies.
Hou, Hsin-Han;Cheng, Shih-Lung;Chung, Kuei-Pin;Kuo, Mark Yen-Ping;Yeh, Cheng-Chang;Chang, Bei-En;Lu, Hsuan-Hsuan;Wang, Hao-Chien;Yu, Chong-Jen +1 more
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Lipid Droplets in Health and Disease
Lipids in Health and Disease, 2017 Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals.
Gizem Onal +3 more
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Chaperone-mediated autophagy and its role in aging [PDF]
, 2021 This review focuses on chaperone-mediated autophagy (CMA). This catabolic process promotes the degradation of intracellular proteins in lysosomes.
Grebnev, D.Y u. +5 more
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Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration
, 2013 alpha-Synuclein levels are critical to Parkinson's disease pathogenesis. Wild-type alpha-synuclein is degraded partly by chaperone-mediated autophagy, and aberrant alpha-synuclein may act as an inhibitor of the pathway.
Stefanis, Leonidas +10 more
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Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
Nature Communications, 2020 Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data ...
S. Dong +6 more
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, 2022 Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the degradation of about 30% of cytosolic proteins, including a series of proteins associated ...
Lu, Jia-Hong +3 more
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