Results 101 to 110 of about 1,561,447 (191)

HSPA8 Chaperone Complex Drives Chaperone-Mediated Autophagy Regulation in Acute Promyelocytic Leukemia Cell Differentiation. [PDF]

INTRODUCTION Acute myeloid leukemia (AML) is a cancer of the hematopoietic system characterized by hyperproliferation of undifferentiated cells of the myeloid lineage.
Mungure, Irene, Müller, Stefan, Kaufmann, Thomas, Muller, Sylviane, Rafiq, Sreoshee, Robert, Guillaume, Torbett, Bruce E, Banz, Yara, Auberger, Patrick, Niklaus, Nicolas J., Humbert, Magali, Jacquel, Arnaud, Tschan, Mario P.   +12 more
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The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

PLoS ONE, 2012
Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and aggregation of mutant Htt in striatal and cortical neurons. Aberrant Htt degradation is implicated in HD pathogenesis.
Qi, Lin, Lin, Fang, Zhang, Xing-Ding, Wu, Jun-Chao, Wang, Jin, DiFiglia, Marian, Qin, Zheng-Hong   +6 more
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The role of chaperone‐mediated autophagy in neurotoxicity induced by alpha‐synuclein after methamphetamine exposure

Brain and Behavior, 2019
Introduction Chaperone‐mediated autophagy (CMA) is an autophagy–lysosome pathway (ALP) that is different from the other two lysosomal pathways, namely, macroautophagy and microautophagy, and can selectively degrade cytosolic proteins in lysosomes without
Leping Sun, Yongling Lian, Jiuyang Ding, Yunle Meng, Chen Li, Ling Chen, Pingming Qiu   +6 more
doaj   +1 more source

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

, 2013
α-Synuclein levels are critical to Parkinson's disease pathogenesis. Wild-type α-synuclein is degraded partly by chaperone-mediated autophagy, and aberrant α-synuclein may act as an inhibitor of the pathway.
Papasilekas, T., Stefanis, L., Landeck, N., Xilouri, M., Kirik, D., Pitychoutis, P.M., Brekk, O.R., Papadopoulou-Daifoti, Z.   +7 more
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Autophagy: mechanisms, roles in human diseases, and therapeutic perspectives

Frontiers in Cell and Developmental Biology
Autophagy, a conserved intracellular degradation and recycling process, maintains cellular homeostasis by eliminating damaged organelles, misfolded proteins, and invading pathogens.
Jiazhen He, Teng Qi
doaj   +1 more source

Voltage-dependent anion channels: different isoforms for different functions [PDF]

, 2009
The Voltage-dependent anion channel (VDAC) is the most abundant protein of the outer mitochondrial membrane (OMM) and mediates the flow of ions and metabolites between the cytoplasm and the mitochondrial network.
DE STEFANI, Diego, De Stefani, D.
core  

Chaperone-mediated autophagy degrades mutant p53

, 2019
Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53 proteins are known to actively contribute to tumor development and metastasis.
Kim, Minsu, Pan, Lifeng, Coloff, Jonathan L., Ofengeim, Dimitry, Brugge, Joan S., Iwanicki, Marcin P., Vakifahmetoglu-Norberg, Helin, Xia, Hong-guang, Ince, Tan A., Yuan, Junying, Kroemer, Guido   +10 more
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chaperone-mediated autophagy

Citation: 'chaperone-mediated autophagy' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12998 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual ...
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Regulation of MEF2s by chaperone-mediated autophagy [PDF]

Cell Cycle, 2009
Qian, Yang, Zixu, Mao
openaire   +4 more sources

Autophagy and aging - The importance of maintaining "clean" cells

, 2005
A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In
Ffrench, Martine,, Cuervo, Ana Maria,, Bergamini, Ettore,, Droge, Wolf,, Brunk, Ulf,, Terman, Alexei,   +5 more
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