Results 71 to 80 of about 1,561,447 (191)

Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice

Frontiers in Pharmacology, 2021
Pancreatic fibrosis is an important pathophysiological feature of chronic pancreatitis (CP). Our recent study has shown that milk fat globule-EGF factor 8 (MFG-E8) is beneficial in acute pancreatitis. However, its role in CP remained unknown.
Yifan Ren, Yifan Ren, Qing Cui, Jia Zhang, Jia Zhang, Wuming Liu, Wuming Liu, Meng Xu, Yi Lv, Yi Lv, Zheng Wu, Yuanyuan Zhang, Rongqian Wu   +12 more
doaj   +1 more source

Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy

Pathogens
Many types of RNA viruses, including the hepatitis C virus (HCV), activate autophagy in infected cells to promote viral growth and counteract the host defense response.
Po-Yuan Ke, Chau-Ting Yeh
doaj   +1 more source

Sequences of Alterations in Inflammation and Autophagy Processes in Rd1 Mice

Biomolecules, 2023
(1) Background: the aim of this work was to study microglia and autophagy alterations in a one retinitis pigmentosa (RP) model at different stages of the disease (when rods are dying and later, when there are almost no rods, and cones are the cells that ...
Javier Martínez-González, Ángel Fernández-Carbonell, Antolin Cantó, Roberto Gimeno-Hernández, Inmaculada Almansa, Francisco Bosch-Morell, María Miranda, Teresa Olivar   +7 more
doaj   +1 more source

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) [PDF]

, 2022
Funding: This work was supported by the National Institute of General Medical Sciences [GM131919].In 2008, we published the first set of guidelines for standardizing research in autophagy.
Autophagy Group, Lucocq, John M., Klionsky, Daniel J.   +2 more
core   +1 more source

Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics

, 2020
As a highly dynamic organelle, mitochondria undergo constant fission and fusion to change their morphology and function, coping with various stress conditions.
Qian Yang (300330), Lin Zhu (192179), Lu Huang (211625), Ruixin Yang (2741125), Pingyi Xu (300227), Tiejian Nie (9718798), Kai Tao (54204), Zixu Mao (9571603), Sijun Hu (2267659)   +8 more
core   +1 more source

MIR376A is a regulator of starvation-induced autophagy [PDF]

, 2013
Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Gozuacik Devrim, Ali Kosar, Korkmaz Gozde, Devrim Gozuacik (498143), Kosar Ali, Gözüaçık, Devrim, Gozuacik, Devrim, Kumsal Ayse Tekirdag (498140), Koşar, Ali, Sezerman, Uğur, Gozde Korkmaz, Ozturk Deniz Gulfem, Gozde Korkmaz (498139), Deniz Gulfem Ozturk, Osman Ugur Sezerman (199388), Sezerman, Osman Ugur, Tekirdag Kumsal Ayse, Korkmaz, Gözde, Tekirdağ, Kumsal Ayşe, Osman Ugur Sezerman, Deniz Gulfem Ozturk (498141), Sezerman Osman Ugur, Özturk, Deniz Gülfem, Kumsal Ayse Tekirdag, Devrim Gozuacik, Ali Kosar (498142)   +25 more
core   +2 more sources

Effects of Small Molecules on Chaperone-Mediated Autophagy [PDF]

Autophagy, 2005
Autophagy, including macroautophagy (MA), chaperone-mediated autophagy (CMA), crinophagy, pexophagy and microautophagy, are processes by which cells select internal components such as proteins, secretory vesicles, organelles, or foreign bodies, and deliver them to lysosomes for degradation. MA and CMA are activated during conditions of serum withdrawal
Patrick F, Finn, Nicholas T, Mesires, Michaela, Vine, J Fred, Dice   +3 more
openaire   +2 more sources

Consequences of the selective blockage of chaperone-mediated autophagy [PDF]

Proceedings of the National Academy of Sciences, 2006
Chaperone-mediated autophagy (CMA) is a selective pathway for the degradation of cytosolic proteins in lysosomes. CMA declines with age because of a decrease in the levels of lysosome-associated membrane protein (LAMP) type 2A, a lysosomal receptor for this pathway.
Ashish C, Massey, Susmita, Kaushik, Guy, Sovak, Roberta, Kiffin, Ana Maria, Cuervo   +4 more
openaire   +2 more sources

Chaperone-Mediated Autophagy and Its Emerging Role in Hematological Malignancies

, 2019
Chaperone-mediated autophagy (CMA) ensures the selective degradation of cellular proteins endowed with a KFERQ-like motif by lysosomes. It is estimated that 30% of all cellular proteins can be directed to the lysosome for CMA degradation, but only a few ...
Patrick Auberger, Guillaume Robert, Arnaud Jacquel   +2 more
core   +1 more source

Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture.

PLoS ONE, 2015
BackgroundHepatic steatosis is a risk factor for both liver disease progression and an impaired response to interferon alpha (IFN-α)-based combination therapy in chronic hepatitis C virus (HCV) infection. Previously, we reported that free fatty acid (FFA)
Ramazan Kurt, Partha K Chandra, Fatma Aboulnasr, Rajesh Panigrahi, Pauline Ferraris, Yucel Aydin, Krzysztof Reiss, Tong Wu, Luis A Balart, Srikanta Dash   +9 more
doaj   +1 more source