Results 51 to 60 of about 1,561,447 (191)

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy [PDF]

Human Molecular Genetics, 2010
Autophagy is the process by which organelles and portions of the cytoplasm are degraded in lysosomes. Several different forms of autophagy are known that are distinguishable chiefly by the mode in which cargo is delivered to the lysosome for degradation.
Cara, Rothenberg, Deepa, Srinivasan, Leann, Mah, Susmita, Kaushik, Corrine M, Peterhoff, Janet, Ugolino, Shengyun, Fang, Ana Maria, Cuervo, Ralph A, Nixon, Mervyn J, Monteiro   +9 more
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Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

Neural Regeneration Research
Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis, while providing nutrients ...
Qi Jia, Jin Li, Xiaofeng Guo, Yi Li, You Wu, Yuliang Peng, Zongping Fang, Xijing Zhang   +7 more
doaj   +1 more source

Chaperone-mediated autophagy: roles in disease and aging [PDF]

Cell Research, 2013
This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate proteins are selectively targeted to lysosomes and translocated into the lysosomal lumen through the coordinated action of chaperones located at both sides of the membrane and a ...
Cuervo, Ana Maria, Wong, Esther
openaire   +4 more sources

The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling

Journal of Virology
This study is the first to reveal that oncolytic avian reovirus (ARV) modulates the IKK/NF-κB signaling through the Hsp90-Cdc37, T-complex protein-1 ring complex (TRiC)/Hsc70, and TRiC-phosducin-like protein 1 (PhLP1) chaperone complexes, thereby ...
Wei‐Ru Huang, Jyun-Yi Li, Tsai-Ling Liao, Lon-Fye Lye, Muhammad Munir, Hung-Jen Liu   +5 more
doaj   +1 more source

Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo

Neurobiology of Disease, 2021
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles.
Federica Albanese, Daniela Mercatelli, Luca Finetti, Giulia Lamonaca, Sara Pizzi, Derya R. Shimshek, Giovanni Bernacchia, Michele Morari   +7 more
doaj   +1 more source

Mechanisms of autophagy and their implications in dermatological disorders

Frontiers in Immunology
Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular ...
Shenghao Xue, Yumeng Lin, Haoran Chen, Zhengyu Yang, Junting Zha, Xuan Jiang, Zhongyu Han, Ke Wang   +7 more
doaj   +1 more source

The complexity in regulation of MEF2D by chaperone-mediated autophagy [PDF]

Autophagy, 2009
Chaperone-mediated autophagy (CMA) targets specific cytoplasmic proteins for degradation by lysosomes and has been implicated to play a role in neurodegeneration. Our recent studies identify neuronal survival factor MEF2D as a direct substrate of CMA and show that dysregulation of this process may contribute to the pathogenesis of Parkinson disease ...
Qian, Yang, Zixu, Mao
openaire   +2 more sources

Autophagy in T Cell Function and Aging

Frontiers in Cell and Developmental Biology, 2019
Dysregulation of autophagy with age has been identified as a central mechanism of aging affecting many cells and tissues. T cells do also show decreased activity with age of different autophagic pathways. Here, we will review the current knowledge of the
Fernando Macian
doaj   +1 more source

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K., Jane P Toegel, Jane P. Toegel (185544), Winklhofer Konstanze F., A Kathrin Lutz, Voigt Aaron, Falkenburger, Bjoern, Toegel Jane P., Konstanze F. Winklhofer (185550), Gerhardt, Ellen, Karsten Peter, A. Kathrin Lutz (185542), Voigt, Aaron, Butler Erin K., Toegel, Jane P., Peter Karsten (123433), Björn Falkenburger (185548), Schulz, Joerg B., Falkenburger, Bjoern H., Peter Karsten, Ellen Gerhardt (185546), Andrea Reinartz (185549), Reinartz, Andrea, Erin K Butler, Ellen Gerhardt, Lutz A. Kathrin, Jörg B Schulz, Gerhardt Ellen, Aaron Voigt (123446), Reinartz Andrea, Jörg B. Schulz (123442), Lutz, A. Kathrin, Karsten, Peter, Konstanze F Winklhofer, Aaron Voigt, Björn Falkenburger, Schulz Jörg B., Erin K. Butler (185540), Winklhofer, Konstanze F., Falkenburger Björn, Andrea Reinartz, Toegel, Jane Patricia   +41 more
core   +2 more sources

Selective Degradation of Annexins by Chaperone-mediated Autophagy [PDF]

Journal of Biological Chemistry, 2000
Annexins are a family of proteins that bind phospholipids in a calcium-dependent manner. Analysis of the sequences of the different members of the annexin family revealed the presence of a pentapeptide biochemically related to KFERQ in some annexins but not in others.
A M, Cuervo, A V, Gomes, J A, Barnes, J F, Dice   +3 more
openaire   +2 more sources