Results 31 to 40 of about 1,561,447 (191)
Identification of Regulators of Chaperone-Mediated Autophagy [PDF]
Molecular Cell, 2010 Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of cytosolic proteins in lysosomes that contributes to cellular quality control and becomes an additional source of amino acids when nutrients are scarce. A chaperone complex delivers CMA substrates to a receptor protein at the lysosomal membrane that assembles into ...
Bandyopadhyay, Urmi +4 more
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Role of chaperone‐mediated autophagy in metabolism [PDF]
The FEBS Journal, 2016 Different types of autophagy coexist in most mammalian cells, and each of them fulfills very specific tasks in intracellular degradation. Some of these autophagic pathways contribute to cellular metabolism by directly hydrolyzing intracellular lipid stores and glycogen.
Inmaculada, Tasset, Ana Maria, Cuervo
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Chaperone‐mediated autophagy: Molecular mechanisms, biological functions, and diseases
MedComm, 2023 Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway that eliminates substrate proteins through heat‐shock cognate protein 70 recognition and lysosome‐associated membrane protein type 2A‐assisted translocation.
Ruchen Yao, Jun Shen
doaj +1 more source
The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2021 Lysosome incorporate and degrade proteins in a process known as autophagy. There are three types of autophagy; macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA).
Chieko Matsui +5 more
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Chaperone-mediated autophagy: roles in neurodegeneration [PDF]
Translational Neurodegeneration, 2014 Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular homeostasis. A growing body of evidence supports the hypothesis that CMA dysfunction may be involved in the pathogenic process of ...
Wang, Gang, Mao, Zixu
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The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
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Methods to study chaperone-mediated autophagy [PDF]
Methods, 2015 Chaperone-mediated autophagy (CMA) is a multistep process that involves selective degradation and digestion of a pool of soluble cytosolic proteins in lysosomes. Cytosolic substrates are selectively identified and targeted by chaperones to lysosomes where they are subsequently translocated into the organelle lumen through a dedicated CMA-associated ...
Bindi, Patel, Ana Maria, Cuervo
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Rapamycin activates mammalian microautophagy
Journal of Pharmacological Sciences, 2019 Autophagy-lysosome proteolysis is classified into macroautophagy (MA), microautophagy (mA) and chaperone-mediated autophagy (CMA). In contrast to MA and CMA, mA have been mainly studied in yeast.
Masahiro Sato +6 more
doaj +1 more source
Autophagy in Drosophila : from historical studies to current knowledge [PDF]
, 2014 The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms.
Nezis, I. P. +13 more
core +1 more source
Chaperone-mediated autophagy protects against hyperglycemic stress
, 2023 Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism, and whose defects have been associated with several human pathologies.
Sara Balbuena-Pecino (13914297) +11 more
core +1 more source