Results 11 to 20 of about 1,561,447 (191)

Chaperone-mediated autophagy regulates adipocyte differentiation

Science Advances, 2022
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes ...
McCabe, Mericka, Gavathiotis, Evripidis, Lindenau, Kristen, Santiago-Fernández, Olaya, Macho González, Adrián, Dong, Suxhian, Kaushik, Susmita, Dong, Shuxian, Juste, Yves, Singh, Rajat, Macho-González, Adrián, Gavathiotis, Evris, Juste, Yves R., Cuervo, Ana Maria   +13 more
core   +4 more sources

Chaperone-mediated autophagy degrades mutant p53 [PDF]

Genes & Development, 2013
Accumulation of mutant p53 proteins contributes to tumor development and metastasis, yet little is known abut how to selectively reduce the cellular load of mutant p53.
Yuan, Junying, Vakifahmetoglu-Norberg, Helin, Pan, Lifeng, Kroemer, Guido, Coloff, Jonathan L, Iwanicki, Marcin P, Xia, Hong-guang, Ofengeim, Dimitry, Brugge, Joan S, Kim, Minsu, Ince, Tan A   +10 more
core   +5 more sources

Targeting Chaperone-Mediated Autophagy in Cancer

Science Translational Medicine, 2011
Tumors need chaperone-mediated autophagy for growth and metastasis.
Jayanta Debnath, Andrew Thorburn
core   +3 more sources

CHAPERONE-MEDIATED AUTOPHAGY PROTECTS AGAINST ATHEROSCLEROSIS

Autophagy, 2022
Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammation and aggravated by aging. As chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation for intracellular proteins, diminishes with ...
Sluimer, Judith C., Sluimer, Judith C; id_orcid, Madrigal-Matute, Julio, Sluimer, Judith C, Cuervo, Ana Maria   +4 more
core   +3 more sources

Chaperone-Mediated Autophagy Is Required for Tumor Growth [PDF]

Science Translational Medicine, 2011
Cancer cells depend on chaperone-mediated autophagy for growth, revealing a new target for preventing tumorigenesis and inducing tumor regression.
Maria Kon, Fernando Macian, Ana Maria Cuervo, Lyuba Varticovski, Roberta Kiffin, Javier Chapochnick, Hiroshi Koga   +6 more
core   +3 more sources

The role of chaperone-mediated autophagy in drug resistance

Genetics and Molecular Biology
In the search for alternatives to overcome the challenge imposed by drug resistance development in cancer treatment, the modulation of autophagy has emerged as a promising alternative that has achieved good results in clinical trials.
Ana Beatriz da Silva Teixeira, Maria Carolina Clares Ramalho, Izadora de Souza, Izabela Amélia Marques de Andrade, Isabeli Yumi Araújo Osawa, Camila Banca Guedes, Beatriz Silva de Oliveira, Cláudio Henrique Dahne de Souza Filho, Tainá Lins da Silva, Natália Cestari Moreno, Marcela Teatin Latancia, Clarissa Ribeiro Reily Rocha   +11 more
doaj   +4 more sources

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

Cells, 2022
Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation.
Simon Schnebert, Maxime Goguet, Emilio J. Vélez, Alexandra Depincé, Florian Beaumatin, Amaury Herpin, Iban Seiliez   +6 more
doaj   +2 more sources

Molecular control of chaperone-mediated autophagy

Essays in Biochemistry, 2017
Chaperone-mediated autophagy (CMA) is a selective form of autophagy in which cytosolic proteins bearing a pentapeptide motif biochemically related to the KFERQ sequence, are recognized by the heat shock protein family A member 8 (HSPA8) chaperone ...
Paulo Pereira, Henrique Girão, Steve Catarino   +2 more
core   +3 more sources

Chaperone-mediated autophagy is required for regulatory T cell function. [PDF]

Nat Commun
Chaperone-mediated autophagy (CMA) is a selective form of protein degradation in lysosomes that declines with age. Besides protein quality control, CMA also regulates several cellular processes through timely proteome remodeling.
Harrison R, Gjergjova F, Pelka S, Macho-Gonzalez A, Chavda B, Lindenau K, Gazteluiturri Garcia A, Khawaja RR, Aguilan JT, Sidoli S, Kaushik S, Botbol Y, Cuervo AM, Macian F.   +13 more
europepmc   +2 more sources

Chaperone-Mediated Autophagy [PDF]

Autophagy, 2007
Chaperone-mediated autophagy (CMA) is a lysosomal pathway of proteolysis that is responsible for the degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation. Molecular chaperones in the cytosol and in the lysosomal lumen stimulate this proteolytic pathway.
Erwin Knecht, Natalia Salvador
openaire   +3 more sources