Results 91 to 100 of about 133 (131)

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Learning From Senior Leaders as a Catalyst for Innovativeness: The Differential Contributions of Supervisors, Coaches, and Mentors Under Varying Task Uncertainty

Creativity and Innovation Management, EarlyView.
ABSTRACT While the literature on employees' innovative work behavior (IWB) treats leaders as a homogeneous source of firm‐internal knowledge, we examine how learning from different types of senior leaders (supervisors, coaches, and mentors) differentially affects employees' IWB and how these effects vary with the uncertainty of work tasks.
Björn Frank, Ei Ei Phyo, Yuosre F. Badir   +2 more
wiley   +1 more source

Cultural and Social Determinants of Indigenous Peoples' Health: Understanding Oral Health Inequities in Canada, New Zealand/Aotearoa, and Australia

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objective This cross‐sectional study examined the cultural and social determinants of health in Canada, New Zealand, and Australia and their relevance to the oral health of Indigenous pregnant women. Methods An Indigenous framework was applied to a social determinants of health (SDH) model, Charlotte Loppie's Tree Metaphor, utilising data from
Herenia P. Lawrence, John R. Broughton, Lisa M. Jamieson   +2 more
wiley   +1 more source

Cumulative Risk and Mental Health of Chinese Rural Adolescents: The Mediation Role of Loneliness and the Moderation Role of Family Functioning

Child &Family Social Work, EarlyView.
ABSTRACT Rural Chinese adolescents face significant mental health challenges shaped by cumulative risks across ecological systems, particularly individual, family and peer domains. However, the underlying mechanism linking cumulative risk to mental health problems remains insufficiently explored.
Chen Deng, Lu Yu, Guowei Wan, Yaoxiang Ren   +3 more
wiley   +1 more source

Start(up) with purpose: How goal‐ and duty‐based purpose drive work engagement and performance in startups

European Management Review, EarlyView.
ABSTRACT Although organizational purpose (OP) has recently gained attention in entrepreneurship research, its motivational potential in startups remains underexplored, limiting the development of effective purpose‐driven strategies to enhance employee work engagement (WE) and startup performance.
Julien A. Nussbaum, Enya Henning, Paulin L. Ostrowski, Dominik K. Kanbach   +3 more
wiley   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Changes in cardiometabolic biomarkers 1 year after direct acting antiviral therapy for hepatitis C virus co‐infection among people with HIV

HIV Medicine, EarlyView.
Abstract Objectives Among people with HIV with hepatitis C virus (HCV) co‐infection, we examined differences in haemoglobin A1c (HbA1c), total cholesterol (TC), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and atherosclerotic cardiovascular disease (ASCVD) risk score at 12‐months following direct acting antiviral (DAA) initiation ...
Raynell Lang, Elizabeth Humes, Asya Lyass, Leila H. Borowsky, Brenna Hogan, Arthur Y. Kim, Michael LaValley, Jennifer O. Lam, Ditipriya Bhar, Richard D. Moore, Frank Palella, Heidi Crane, Michael Horberg, Sonia Napravnik, Virginia A. Triant, Keri N. Althoff, on behalf of the North American AIDS Cohort Collaboration on Research and Design (NA‐ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA)   +16 more
wiley   +1 more source

Differentiated by Design? Cross‐Border Cooperation in Europe as Differentiated Integration From Below

JCMS: Journal of Common Market Studies, EarlyView.
Abstract Differentiated integration has become a central concept in contemporary theorizing about European integration, reflecting the increasingly multi‐speed, multi‐tier and multi‐menu nature of integration within the European Union (EU). This research note extends the conceptual lens of differentiated integration to the level of cross‐border regions.
Georg Wenzelburger, Stefanie Thurm
wiley   +1 more source

Open Innovation for Circular Business Models: Addressing the Right Challenge at the Right Time

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary In response to escalating societal challenges, such as climate change and resource constraints, this article examines the transition from linear toward circular business models (CBMs). It explores the challenges of CBM transitions and how to tackle them through open innovation.
Daniel Wörner, Lukas Falcke, Manuel Ritter, Shaun West, Thomas Friedli   +4 more
wiley   +1 more source