Results 111 to 120 of about 140 (138)

A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2‐Positive Metastatic Breast Cancer

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Ibrutinib has demonstrated inhibition of ErbB/HER tyrosine kinases in preclinical models. This Phase I/II study investigated the safety, efficacy, and immunomodulatory effects of ibrutinib in combination with trastuzumab in patients with HER2‐positive metastatic breast cancer (MBC) whose disease had progressed on ado‐trastuzumab emtansine ...
Joyce O'Shaughnessy, Andrea Glidden, Tracy Locke, Amy Scales, Elizabeth Gatewood, Jean‐Philippe Blanck, Jessica Castaneda‐Gill, Sharlin Patel, Yolanda D. Mahnke, Xuan Wang, Page Blas   +10 more
wiley   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

Identifying climatic refugia: Wet and complex habitats act as buffer for birds during severe droughts

Journal of Applied Ecology, Volume 63, Issue 8, August 2026.
Wet habitats and complex vegetation, therefore, are critical for providing stable microsites and water resources, underscoring the need to preserve and enhance the resilience of these habitats to support biodiversity during extreme events. Our study provides valuable insights for conservation strategies that should focus on identifying refugia ...
Jordi Vázquez‐Recasens, Joan Real, Roger Puig‐Gironès   +2 more
wiley   +1 more source

Intracerebral Haemorrhage in the Top End of the Northern Territory; Risk Factors, Outcomes and the Presence of Cerebral Amyloid Angiopathy in Indigenous Peoples

Australian Journal of Rural Health, Volume 34, Issue 4, August 2026.
ABSTRACT Objective The prevalence of intracranial haemorrhage (ICH) and cerebral amyloid angiopathy (CAA) in the Northern Territory (NT) is unknown. This study aims to improve knowledge of haemorrhagic stroke in the NT, to evaluate the relevance of CAA and examine its association with chronic kidney disease (CKD).
Marianna Diamandopoulos, Alvaro Cervera, Geoffrey A. Donnan   +2 more
wiley   +1 more source

Comparative endocranial anatomy in the crocodylians Leidyosuchus canadensis and Stangerochampsa mccabei from the upper Cretaceous of Alberta, Canada

Journal of Anatomy, Volume 249, Issue 2, Page 264-291, August 2026.
Leidyosuchus canadensis and Stangerochampsa mccabei share endocranial features such as posterior projection of a neurovascular canal in the maxilla and a paratympanic sinus system most similar to those of small‐bodied and young extant crocodylians, suggesting that these pedomorphic features may reflect the ancestral crocodylian condition.
G. Donzé, G. Perrichon, P. Vincent, F. Therrien, J. E. Martin   +4 more
wiley   +1 more source

Mechanical Loading Induces Distinct and Shared Responses in Endothelial and Muscle Cells and Reveals Exercise‐Like Molecular Profiles

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Mechanical loading of human endothelial and muscle cells induced several distinct and shared molecular responses, many of which are commonly observed after exercise in vivo. Both cell types secreted acetate and endothelial cells increased serine synthesis from glucose.
Sakari Mäntyselkä, Erik Niemi, Laura Ylä‐Outinen, Kalle Kolari, Liina Uusitalo‐Kylmälä, Alfredo Ortega‐Alonso, Roosa‐Maria Liimatainen, Vasco Fachada, Perttu Permi, Elina Kalenius, Juha J. Hulmi, Riikka Kivelä   +11 more
wiley   +1 more source

Centriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The identification of a patient carrying a novel homozygous p.(Gln206Ter) POC5 variant revealed a metabolic phenotype associated with POC5 deficiency. POC5 deficiency disrupts centriolar architecture and ciliary organization, leading to impaired proliferation, premature cellular senescence, and reduced insulin signaling.
Valeria Pistorio, Camille Vatier, Émilie Capel, Carine Beaupère, Martine Auclair, Virginie Steunou, Romain Morichon, Michael Joubert, Corinne Vigouroux, Jérémie Gautheron, Isabelle Jéru   +10 more
wiley   +1 more source

Calcium Solubility of Bridgmanite in Subducted Basalt in Earth's Lower Mantle

Geophysical Research Letters, Volume 53, Issue 14, 28 July 2026.
Abstract The calcium solubility in bridgmanite and the resulting abundance of davemaoite under lower‐mantle pressure‐temperature conditions have been under debate following a recent report of extensive calcium dissolution in bridgmanite. We experimentally investigated the calcium solubility in bridgmanite in a basaltic composition at pressures up to ...
Chengwei Zhang, Takashi Yoshino, Elias El Ghazaoui, Stella Chariton, Vitali B. Prakapenka, Luo Li, Yanyao Zhang, Jung‐Fu Lin   +7 more
wiley   +1 more source

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Application of the EGSB-CMBR Process to High-Concentration Organic Wastewater Treatment

Processes, 2022
Wang Dunqiu, Dunqiu Wang
exaly  

Suppression of membrane fouling in the ceramic membrane bioreactor (CMBR) by minute electric field

Bioresource Technology, 2018
Wentao Shang, Mu Li, Zijun Dong
exaly