Results 41 to 50 of about 46,232 (300)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Book Review: CONSIDERATIONS ABOUT A FUNDAMENTAL BOOK OF ROMANIAN MUSICOLOGY

Studia Universitatis Babeş-Bolyai. Musica, 2018
Written on commission and published in 1997, awarded with the prize for musicology by the Romanian Union of Composers and Musicologists in 1999, this book, entitled Orientări, direcții, curente ale muzicii românești din a doua jumătate a secolului XX ...
Oleg GARAZ
doaj   +2 more sources

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

CMD 2020 Opinion [PDF]

2020 8th International Conference on Condition Monitoring and Diagnosis (CMD), 2020
  +12 more sources

Differential Interaction of High Microvascular Resistance With Coronary Flow Reserve Across Coronary Microvascular Dysfunction Endotypes

JACC: Advances
Background: In contrast to reduced coronary flow reserve (CFR), increased minimal hyperemic microvascular resistance (hMR) lacks prognostic relevance in stable chronic coronary syndromes.
Ahmet Tas, MD, Yaren Alan, MD, Peter Damman, MD, PhD, Tim P. van de Hoef, MD, PhD, Ilke Kara Tas, MD, Elif Gül Türkmenoğlu, BSc, Niels van Royen, MD, Divaka Perera, MD, Sabahattin Umman, MD, Kim H. Parker, PhD, Jan J. Piek, MD, PhD, Murat Sezer, MD   +11 more
doaj   +1 more source

Prevalence of CMD and PTSD.

, 2016
Prevalence of CMD and PTSD.
Crick Lund (291701), Charlotte Clark (324008), Stephen Stansfeld (324009), Jayati Das-Munshi (2637316), Catherine Mathews (621273), Catherine Rothon (2637313)   +5 more
core   +1 more source

Challenges and Opportunities in Multi‐Method Integrated Geophysical Prospection of Buried Building Remains at the Sanctuary of Olympia

Archaeological Prospection, EarlyView.
ABSTRACT Ancient Olympia was one of the most important sanctuaries and the venue for the Olympic Games in Greek and Roman times. Its remains are located in the Olympia Terrace (Peloponnese, Greece) at the present‐day confluence of the rivers Alpheios and Kladeos at the base of Mount Kronos.
Sarah Bäumler, Dennis Wilken, Peter Fischer, Lena Slabon, Timo Willershäuser, Birgitta Eder, Hans‐Joachim Gehrke, Erofili‐Iris Kolia, Franziska Lang, Oliver Pilz, Andreas Vött   +10 more
wiley   +1 more source

Recent results from CMD-3

, 2019
Regular data taking with the CMD-3 at the electron-positron collider VEPP-2000 is under way since 2010. The collected data sample corresponds to about 200 inverse picobarns of integrated luminosity per detector in the energy range from 0.32 up to 2 GeV ...
A. E. Ryzhenenkov, N. S. Bashtovoy, V. E. Shebalin, Yu. N. Pestov, V. F. Kazanin, A. S. Popov, P. P. Krokovny, D. B. Shwartz, A. N. Kozyrev, V. M. Aulchenko, A. A. Ruban, A. S. Kuzmin, G. P. Razuvaev, Yu. M. Shatunov, F. V. Ignatov, V. Sh. Banzarov, D. A. Epifanov, G. V. Fedotovich, A. E. Kuzmenko, S. I. Eidelman, Yu. A. Rogovsky, L. B. Epshteyn, A. I. Vorobiov, A. N. Kirpotin, I. A. Koop, D. N. Shemyakin, B. A. Shwartz, I. B. Logashenko, I. M. Zemlyansky, E. P. Solodov, A. A. Grebenuk, A. L. Erofeev, E. A. Kozyrev, A. N. Amirkhanov, V. M. Titov, V. L. Ivanov, N. M. Ryskulov, A. V. Bragin, S. S. Gribanov, S. V. Karpov, A. V. Semenov, P. Yu. Shatunov, A. V. Anisenkov, D. N. Grigoriev, A. A. Talyshev, A. L. Sibidanov, D. E. Berkaev, V. S. Okhapkin, R. R. Akhmetshin, P. A. Lukin, K. Yu. Mikhailov, Yu. V. Yudin, A. E. Bondar, S. E. Gayazov, A. A. Korobov   +54 more
core   +1 more source

Poseidon's Sanctuary at Samikon—The Discovery of an Ancient Temple Through an Integrated Geophysical and Geoarchaeological Survey Approach for Lagoonal and Swampy Environments

Archaeological Prospection, EarlyView.
ABSTRACT Below the classical fortress of Samikon at the coast of the western Peloponnese, ancient writer Strabo mentioned a sanctuary of Poseidon which served as the centre of the religious association of the Triphylian cities. In this paper, we describe the discovery and investigation of a building structure by means of geophysical and ...
Dennis Wilken, Birgitta Eder, Sarah Bäumler, Elena Appel, Peter Fischer, Tina Georg, Federica Iannone, Lena Slabon, Timo Willershäuser, Erofili‐Iris Kolia, Andreas Vött   +10 more
wiley   +1 more source

Real world data on cardiometabolic diseases in U.S. adults during the SARS-CoV-2 pandemic: a decentralized registry study

Cardiovascular Diabetology, 2022
Background Pre-existing cardiometabolic comorbidities place SARS-CoV-2 positive patients at a greater risk for poorer clinical course and mortality than those without it. We aimed to analyze real-world registry data focused primarily on participants with
Parth Shah, Kim Magee, Kiara H. Buccellato, McKenna Ismond, Jalisa Watson   +4 more
doaj   +1 more source