Results 41 to 50 of about 9,322 (207)

Mouse adipose tissue stromal cells give rise to skeletal and cardiomyogenic cell sub-populations

Frontiers in Cell and Developmental Biology, 2014
We previously reported that adipose tissue could generate cardiomyocyte-like cells from crude stromal vascular fraction (SVF) in vitro that improved cardiac function in a myocardial infarction context.
Cécile eDromard, Cécile eDromard, Cécile eDromard, Cécile eDromard, Corinne eBarreau, Corinne eBarreau, Corinne eBarreau, Corinne eBarreau, Mireille eAndré, Mireille eAndré, Mireille eAndré, Sandra eBerger-Müller, Sandra eBerger-Müller, Sandra eBerger-Müller, Louis eCasteilla, Louis eCasteilla, Louis eCasteilla, Louis eCasteilla, Valerie ePlanat-Benard, Valerie ePlanat-Benard, Valerie ePlanat-Benard, Valerie ePlanat-Benard   +21 more
doaj   +1 more source

Field Studies on the Influence of High‐Voltage Direct Transmission Underground Cables on Soils Along the SuedLink Route in Southwest Germany

Journal of Plant Nutrition and Soil Science, EarlyView.
During regular operation of the SuedLink at a load ≤75 %, the average increase in temperature in the plowing horizon is expected to be less than 1.6°C in the soils along the route in Southwest Germany. ABSTRACT Background The SuedLink was planned as a high‐voltage direct‐current underground cable route. The construction itself is a massive intervention
Joachim Ingwersen, Alexander Schade, Andreas Lehmann, Jonas Trenz, Maja Schreiber, Christoph Drefke, Harald Schramm, Christian Bidlingmaier, Simone Graeff‐Hönninger, Thilo Streck, Karl Wieland   +10 more
wiley   +1 more source

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Cell Reports, 2019
Summary: Disassembly of the replisome is the final step of chromosome duplication in eukaryotes. In budding yeast and metazoa, cullin ubiquitin ligases are required to ubiquitylate the Cdc45-MCM-GINS (CMG) helicase that lies at the heart of the replisome,
Progya P. Mukherjee, Karim P.M. Labib
doaj   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair

Bioactive Materials
Critical limb ischemia (CLI) is a devastating disease characterized by the progressive blockage of blood vessels. Although the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI, poor cell survival in ...
Haeun Chung, Jung-Kyun Choi, Changgi Hong, Youngseop Lee, Ki Hyun Hong, Seung Ja Oh, Jeongmin Kim, Soo-Chang Song, Jong-Wan Kim, Sang-Heon Kim   +9 more
doaj   +1 more source

Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units

Genome Medicine, 2021
Background Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to improve antimicrobial treatment and infection control decisions.
Themoula Charalampous, Adela Alcolea-Medina, Luke B. Snell, Tom G. S. Williams, Rahul Batra, Christopher Alder, Andrea Telatin, Luigi Camporota, Christopher I. S. Meadows, Duncan Wyncoll, Nicholas A. Barrett, Carolyn J. Hemsley, Lisa Bryan, William Newsholme, Sara E. Boyd, Anna Green, Ula Mahadeva, Amita Patel, Penelope R. Cliff, Andrew J. Page, Justin O’Grady, Jonathan D. Edgeworth   +21 more
doaj   +1 more source

The eukaryotic CMG helicase pumpjack and integration into the replisome [PDF]

Nucleus, 2016
The eukaryotic replisome is α multiprotein machine that contains DNA polymerases, sliding clamps, helicase, and primase along with several factors that participate in cell cycle and checkpoint control. The detailed structure of the 11-subunit CMG helicase (Cdc45/Mcm2-7/GINS) has been solved recently by cryoEM single-particle 3D reconstruction and ...
Sun, Jingchuan, Yuan, Zuanning, Georgescu, Roxanna, Li, Huilin, O'Donnell, Mike   +4 more
openaire   +2 more sources

Delayed reconstruction is associated with higher rates of medial meniscus and chondral injury following ACL injury: A New Zealand ACL Registry Study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Early reconstruction for anterior cruciate ligament (ACL) rupture may be controversial, with some clinicians opting for a trial of non‐operative management first. The impact of delayed surgery on outcomes is unclear, but it may be associated with an increase in secondary intra‐articular pathology involving the menisci and cartilage ...
Richard Rahardja, Hamish Love, Mark G. Clatworthy, Simon W. Young   +3 more
wiley   +1 more source

Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

, 2023
Abstract The human CMG helicase (Cdc45-MCM-GINS) is a novel target for anti-cancer therapy due to tumor-specific weaknesses in CMG function induced by oncogenic changes and the need for CMG function during recovery from replicative stresses such as chemotherapy.
Mark Alexandrow, Shengyan Xiang, Xingju Luo, Darcy Welch, Damon Reed   +4 more
openaire   +2 more sources

Improving the Patient Experience in Pediatric Cystometrography: A Prospective Observational Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Cystometrography, despite its invasive nature, is a crucial investigation for understanding and managing the bladder in children with neurogenic, non‐neurogenic and congenital bladder conditions. Results are influenced by child behaviors and artefacts, but results can be critical in developing patient‐specific management plans ...
Assia Comella, Amy Bodley, Hayley Nugara, Edwina Mcdonald, Neil Price, Elizabeth Dally, Chris Kimber, Kiarash Taghavi   +7 more
wiley   +1 more source