Results 161 to 170 of about 70,006 (218)

Rapid Transformation to Myeloid Blast Crisis in a Pediatric CML Patient Harboring a Complex t(7;9;22)(q11.23;q34;q11.2) Variant Translocation: A Case Report. [PDF]

EJHaem
Haidary AM, Noor S, Hussaini N, Amarkhail A, Ahmad M, Muhib I, Esmat E, Malakzai HA, Hakimi A, Haidari M, Ibrahimkhil AS, Saadaat R.   +11 more
europepmc   +1 more source

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source

Kinase inhibition rewires the HLA-I immunopeptidome in chronic myeloid leukemia. [PDF]

iScience
Venafra V, Wahle M, Massacci G, Bica V, Chiusolo P, Mougiakakos D, Boettcher M, Fischer T, Perfetto L, Mann M, Sacco F.   +10 more
europepmc   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Serum carboxymethyl-lysine levels inversely correlate with appendicular skeletal muscle index in female patients with non-dialysis chronic kidney disease. [PDF]

BMC Nephrol
Yang Y, Li Y, Fan Y, Liu Y, Hu S, Wen L, Zhu P, Li C, Tan R.   +8 more
europepmc   +1 more source

Concurrent <i>SF3B1</i> Mutation and <i>BCR::ABL1</i> Demonstrating a Myelodysplastic Syndrome Phenotype: A Case Report. [PDF]

EJHaem
Brailovski E, Vahedi A, Lisi V, Dmitrienko S, Mercier FE, Lavallée VP, Assouline S.   +6 more
europepmc   +1 more source

Molecular Insights and Repellent Efficacy of the Essential Oil and Major Compounds From Piper cyrtopodon (Miq.) C.DC (Piperaceae) Against Aedes aegypti (Linnaeus, 1762) (Culicidae)

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
The essential oil and major compounds from Piper cyrtopodon exhibit potent, long‐lasting repellent activity against Aedes aegypti mosquitoes, combined with low cytotoxicity and favorable molecular docking interactions with odorant‐binding proteins. These findings highlight its potential for the development of alternative products for bite prevention ...
Maria L. L. da Costa, Renata G. de Azevedo, Sergio M. Nunomura, Rita de C. S. Nunomura, Gemilson S. Pontes, Rosemary A. Roque, Tatiane P. de Souza, André C. de Oliveira   +7 more
wiley   +1 more source

A CML Patient with Unintentional Bosutinib Exposure During the First Trimester of Pregnancy [PDF]

Turk J Haematol
Küçükbaş Özönder GN, Terzi Demirsoy E, Mehtap Ö, Metli K.   +3 more
europepmc   +1 more source

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Our integrative Mendelian randomization framework revealed that specific circulating metabolites exert causal effects on major depressive disorder, partly through immune‐cell–mediated pathways. These findings highlight metabolite–immune interactions as potential mechanistic targets for MDD prevention and therapy.
Zhiwei Xu, Yining Zhou, Xuecheng Zhang, Xiaowen Chen, Yajing Li, Jintao Wang, Ting Chang, Zhen Yuan, Hongling Jia   +8 more
wiley   +1 more source

Long-term outcomes of low-dose dasatinib in older patients with chronic myeloid leukemia in chronic phase: an extended follow-up of the DAVLEC phase 2 trial. [PDF]

Blood Cancer J
Ureshino H, Murai K, Kumagai T, Mino T, Nishiwaki K, Wakita S, Takeoka T, Mita M, Yoshida C, Uoshima N, Fukushima T, Kuroda J, Kondo T, Chiba M, Miyazaki T, Io K, Ueda T, Ono T, Usuki K, Yamauchi T, Fujimaki K, Ikezoe T, Kawaguchi A, Kimura S.   +23 more
europepmc   +1 more source