Results 31 to 40 of about 216,439 (378)

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.

New England Journal of Medicine, 2004
BACKGROUND The progression of chronic myelogenous leukemia (CML) to blast crisis is supported by self-renewing leukemic stem cells. In normal mouse hematopoietic stem cells, the process of self-renewal involves the beta-catenin-signaling pathway.
C. Jamieson, L. Ailles, S. Dylla, M. Muijtjens, Carol D. Jones, J. Zehnder, J. Gotlib, Kevin Li, M. Manz, A. Keating, C. Sawyers, I. Weissman   +11 more
semanticscholar   +1 more source

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]

, 2019
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton, A Kuma, AS Corbin, B Ronan, B Zhang, B Zhang, BJ Druker, C Bellodi, D Mahalingam, DJ Klionsky, DT Vogl, E Weisberg, F Liu, G Karsli-Uzunbas, JD Mancias, JY Guo, JY Guo, M Karvela, M Komatsu, M Mortensen, M Schemionek, MR Rosenfeld, MR Warr, MT Rosenfeldt, N Mizushima, P Rousselot, Q McAfee, R Bago, R Rangwala, R Rangwala, S Brenner, S Kimura, S Koschmieder, SM Graham, T Holyoake, TL Holyoake, TL Holyoake, TT Ho, V Kirkin, VW Rebecca, WE Dowdle, XH Ma, Z Tothova   +42 more
core   +2 more sources

Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group

Pediatric Blood & Cancer, 2019
Chronic myeloid leukemia (CML) accounts for 2‐3% of leukemias in children under 15 and 9% in adolescents aged 15‐19. The diagnosis and management of CML in children, adolescents, and young adults have several differences compared to that in adults.
U. Athale, N. Hijiya, B. Patterson, J. Bergsagel, J. Andolina, H. Bittencourt, K. Schultz, M. Burke, M. Redell, E. Kolb, D. Johnston   +10 more
semanticscholar   +1 more source

CMLLite: a design philosophy for CML [PDF]

Journal of Cheminformatics, 2011
CMLLite is a collection of definitions and processes which provide strong and flexible validation for a document in Chemical Markup Language (CML). It consists of an updated CML schema (schema3), conventions specifying rules in both human and machine-understandable forms and a validator available both online and offline to check conformance.
Townsend, Joe A, Murray-Rust, Peter
openaire   +4 more sources

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.

Journal of Clinical Investigation, 2019
Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the BCR-ABL kinase. Despite the success of BCR-ABL tyrosine kinase inhibitors (TKIs) in treating CML patients, leukemia stem cells (LSCs) resist elimination and persist
Ajay Abraham, S. Qiu, B. Chacko, Hui Li, A. Paterson, Jianbo He, Puneet Agarwal, Mansi Shah, R. Welner, V. Darley-Usmar, R. Bhatia   +10 more
semanticscholar   +1 more source

CML patients with deep molecular responses to TKI have restored immune effectors and decreased PD-1 and immune suppressors.

Blood, 2017
Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment-free remission (TFR).
Amy Hughes, J. Clarson, Carine Tang, L. Vidovic, D. White, T. Hughes, A. Yong   +6 more
semanticscholar   +1 more source

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

Meeting the needs of CML patients in resource-poor countries.

Hematology. American Society of Hematology. Education Program, 2019
Subsequent to the development and global availability of BCR/ABL-targeted tyrosine kinase inhibitors (TKIs), the prognosis of patients with chronic myeloid leukemia (CML), at least those in the chronic phase, has markedly improved, and in the developed ...
H. Malhotra, J. Radich, Pat Garcia-Gonzalez   +2 more
semanticscholar   +1 more source

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors [PDF]

, 2014
Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR-ABL which activates a number of signal transduction pathways, including PI3K/AKT signaling and consequently inactivates FOXO transcription factors.
Bhatia, Birkenkamp, Breitling, Bruennert, Brunet, Burgering, Chomel, Chu, Copland, Corbin, Druker, Duy, Essafi, Fernandez de Mattos, Ghaffari, Goldman, Graham, Hamilton, Hurtz, Ito, Jorgensen, Kikuchi, Komatsu, Koschmieder, Mahon, Matsumoto, Miyamoto, Naka, Pellicano, Pellicano, Pellicano, Ross, Ross, Rowley, Sarbassov, Skorski, Tothova, Tothova, Trotman   +38 more
core   +2 more sources

A Review of Remote Sensing Challenges for Food Security with Respect to Salinity and Drought Threats

Remote Sensing, 2020
Drought and salinity stress are considered to be the two main factors limiting crop productivity. With climate change, these stresses are projected to increase, further exacerbating the risks to global food security. Consequently, to tackle this problem,
Wen Wen, Joris Timmermans, Qi Chen, Peter M. van Bodegom   +3 more
doaj   +1 more source