Results 41 to 50 of about 70,006 (218)

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, EarlyView.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Can we project well-being? Towards integral well-being projections in climate models and beyond

Humanities & Social Sciences Communications
Scientists have proposed many “Beyond-GDP” indicators to replace the Gross Domestic Product (GDP) in order to quantify genuine societal development. While GDP is regularly projected, research on future trajectories of Beyond-GDP indicators is lacking ...
Kedi Liu, Ranran Wang, Inge Schrijver, Rutger Hoekstra   +3 more
doaj   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Evaluation of Imatinib adherence in chronic myeloid leukemia patients in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background: Chronic myeloid leukemia is a clonal myeloproliferative neoplasm that results in proliferation, mainly of granulocytic components. Resulting from t(9;22) with fusion oncogen BCR-ABL1 which has uninhibited tyrosine kinase activity.
Athmar Kadhim Gatea, Mohammed Ali Al-Jabory, Noor Hasan Baiee   +2 more
doaj   +1 more source

Oxidative Fast Pyrolysis Enabling Autothermal Production of Porous Functionalized Biochar and Anhydrosugar/Phenol‐Rich Bio‐Oil From Biomass

Carbon Energy, EarlyView.
Oxidative fast pyrolysis of biomass enables autothermal production of value‐added products. ABSTRACT Oxidative fast pyrolysis can potentially overcome the heat‐supply bottleneck of conventional fast pyrolysis by enabling autothermal operation while also tailoring product quality through controlled oxygen addition.
Bin Li, Mengge Song, Sunwen Xia, Kexin Jia, Wojciech Jerzak, Yusuf Makarfi Isa, Dongjing Liu, Xing Xie, Qingfa Zhang, Zhong Ma, Mingfeng Wang, Weiwei Liu, Shihong Zhang, Haiping Yang, Rock Keey Liew, Su Shiung Lam   +15 more
wiley   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Generative Artificial Intelligence in education: Models, Frameworks and the proposal for a new vertical K‐12 Digital Curriculum

The Curriculum Journal, EarlyView.
Abstract This contribution critically analyses the main international educational frameworks for teachers' digital competence, highlighting both critical issues and potential in relation to their professional development and the need to update school curricula.
Daniela Marzano, Roberto Maniglio, Antonella Senese, Guglielmina Diolaiuti   +3 more
wiley   +1 more source

Electrospun Biomass‐Derived Flexible Anodes With Hierarchical Structure via Cobalt MOF Integration for Sodium‐Ion Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Hierarchically porous, N‐doped freestanding anode enables reversible Na+ insertion/desorption and Na–Co alloying, delivering fast kinetics, structural robustness, and durable sodium‐storage performance even under bending/folding. To develop a green, sustainable, and high‐performance anode for sodium‐ion batteries (SIBs), flexible biomass‐based carbon ...
Yuqiong He, Shengping Hou, Jie Liu, Shengbo Ge, Siqun Wang, Mashallah Rezakazemi, Feng Liang, Guanben Du, Kaimeng Xu   +8 more
wiley   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different?

ESC Heart Failure, Volume 12, Issue 2, Page 1447-1454, April 2025.
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Cristina Madaudo, Daniela Di Lisi, Antonio Cannatà, Federica Manfrè, Celeste Vullo, Marco Santoro, Ciro Botta, Salvatrice Mancuso, Sergio Siragusa, Alfredo Ruggero Galassi, Giuseppina Novo   +10 more
wiley   +1 more source

A Review of Remote Sensing Challenges for Food Security with Respect to Salinity and Drought Threats

Remote Sensing, 2020
Drought and salinity stress are considered to be the two main factors limiting crop productivity. With climate change, these stresses are projected to increase, further exacerbating the risks to global food security. Consequently, to tackle this problem,
Wen Wen, Joris Timmermans, Qi Chen, Peter M. van Bodegom   +3 more
doaj   +1 more source