Results 51 to 60 of about 72,198 (215)

Treatment-Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure. [PDF]

Cancer Sci
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Ureshino H, Kimura S.
europepmc   +2 more sources

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia

Biotechnology Progress, EarlyView.
Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng, Huajian Chen, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +6 more
wiley   +1 more source

Enhancing Maritime Navigation with Mixed Reality: Assessing Remote Pilotage Concepts and Technologies by In Situ Testing

Journal of Marine Science and Engineering
In response to the evolving landscape of maritime operations, new technologies are on the horizon as mixed reality (MR), which shall enhance navigation safety and efficiency during remote assistance as, e.g., in the remote pilotage use case.
Arbresh Ujkani, Pascal Hohnrath, Robert Grundmann, Hans-Christoph Burmeister   +3 more
doaj   +1 more source

The Impact of Glycation on Protein Digestibility

ChemFoodChem, EarlyView.
Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann, Simone Lipinski, Jana Raupbach   +2 more
wiley   +1 more source

Ammonia emissions from agricultural products at high resolution across Europe

Scientific Data
Ammonia (NH3) has significant adverse effects on biodiversity, human and ecosystem health. More than 90% of European NH3 emissions originate from manure and synthetic fertilizer.
Xinpeng Jin, Paul Behrens, Jan Willem Erisman, José M. Mogollón   +3 more
doaj   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Vertical farming economics: crop performance targets for cost-competitive vertical farming

Frontiers in Sustainable Food Systems
Vertical farming may offer a scalable solution to land, water, and climate constraints in agriculture, yet its viability hinges on reducing energy and capital costs. Despite these promises, the economic competitiveness of VF is strongly contested.
G. J. J. M. Meeuws, G. J. J. M. Meeuws, D. J. Heeling, A. van Stuijvenberg, J. M. Mogollón, J. W. Erisman, P. A. Behrens, P. A. Behrens   +7 more
doaj   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

Urban efficiency and rural redundancy: global transportation infrastructure resource demand from 2010–2070

Environmental Research: Infrastructure and Sustainability
Transportation infrastructure stocks are a large share of global material stock, comprising around 30%–50% of global material stock. As emerging economies expand and developed nations have growing maintenance needs, increasing material demand presents a ...
Martijn van Engelenburg, Ester van der Voet, Sebastiaan Deetman, Tomer Fishman, Paul Behrens, Peter Berrill   +5 more
doaj   +1 more source