Results 31 to 40 of about 70,006 (218)
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Refining maritime Automatic Speech Recognition by leveraging synthetic speech
Maritime Transport ResearchMaritime transport serves as a critical component of global trade and logistics, enabling the movement of goods and resources across oceans and waterways.
Christoph Martius +3 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
A comprehensive Beyond-GDP database to accelerate wellbeing, inclusion, and sustainability research
Scientific Data“Beyond-GDP” metrics are essential for understanding societal progress. Yet despite their importance, these metrics are scattered across various databases, hindering accessibility and interdisciplinary analysis.
Kedi Liu +6 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng +8 more
wiley +1 more source
Economic viability requires higher recycling rates for imported plastic waste than expected
Nature CommunicationsThe environmental impact of traded plastic waste hinges on how it is treated. Existing studies often use domestic or scenario-based recycling rates for imported plastic waste, which is problematic due to differences in recyclability and the fact that ...
Kai Li +3 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source
Step‐by‐Step Technique for Platelet‐Rich Plasma Gel Preparation and Use in Knee Osteoarthritis
Arthroscopy Techniques, EarlyView.Abstract Knee osteoarthritis (OA) remains a leading cause of pain and disability worldwide, and current injectable options such as corticosteroids and hyaluronic acid often provide limited or short‐term benefits. Orthobiologic therapies, particularly platelet‐rich plasma (PRP), have gained attention for their regenerative and anti‐inflammatory ...
Diego Ariel de Lima +6 more
wiley +1 more source
Lawsonella clevelandensis as the causative agent of a breast abscess
IDCases, 2018 Lawsonella clevelandensis is a Gram-stain-positive, partially acid-fast, anaerobic, being considered a new species within a new genus in the suborder Corynebacterineae. There are only a few cases reported worldwide.
M. Favila Menezes +5 more
doaj +1 more source