Results 61 to 70 of about 195,243 (312)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Nanocarriers as Magic Bullets in the Treatment of Leukemia

Nanomaterials, 2020
Leukemia is a type of hematopoietic stem/progenitor cell malignancy characterized by the accumulation of immature cells in the blood and bone marrow. Treatment strategies mainly rely on the administration of chemotherapeutic agents, which, unfortunately,
Mohammad Houshmand, Francesca Garello, Paola Circosta, Rachele Stefania, Silvio Aime, Giuseppe Saglio, Claudia Giachino   +6 more
doaj   +1 more source

Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal [PDF]

, 2018
Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC ...
Busch, Caroline, Copland, Mhairi, Jørgensen, Heather, Morrison, Heather, O'Brien, Stephen, Toofan, Parto, Wheadon, Helen   +6 more
core   +2 more sources

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Impacts of a nano-enabled pesticide formulation (nTiO2-coated carbendazim) and its constituents on the freshwater snail Lymnaea stagnalis & damselfly Ischnura elegans assessed via in-situ bioassays

Ecotoxicology and Environmental Safety
Novel pesticidal products in which active substances are delivered via nanoscale carrier systems have been suggested to offer functional and environmental benefits over conventional pesticide formulations. Nevertheless, non-target impacts associated with
Tom A.P. Nederstigt, Richard K.M. Frische, Jesse Ouwehand, Martina G. Vijver   +3 more
doaj   +1 more source

Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment

Antioxidants, 2020
Chronic myeloid leukaemia (CML) is currently treated with inhibitors of the CML specific oncoprotein, bcr-abl. While this strategy is initially successful, drug resistance can become a problem.
Erin Clapper, Sicong Wang, Prahlad V. Raninga, Giovanna Di Trapani, Kathryn F. Tonissen   +4 more
doaj   +1 more source

The effects of time valuation in cancer optimal therapies: a study of chronic myeloid leukemia [PDF]

, 2019
Background The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, however, cancer optimal therapies
Gutiérrez Díez, Pedro José
core   +2 more sources

Super‐Robust Telecommunications Enabled by Topological Half‐Supermodes

Advanced Science, EarlyView.
Through topological half‐supermode engineering, we realize a valley‐ridge gap waveguide that is directly compatible with conventional waveguides and features topological protection. This design halves the lateral size via a PEC boundary, enabling direct TE₁₀‐mode matching and robust bend‐immune transmission.
Rui Zhou, Xintong Shi, Hai Lin, Yan Ren, Hang Liu, Zihao Yu, Jing Jin, Zhihao Lan, Menglin L. N. Chen   +8 more
wiley   +1 more source

The FOod Commodity composition for Waste qUantification and valorization opportunitieS (FOWCUS) Dataset

Scientific Data
This study introduces FOWCUS, a novel dataset detailing the composition of about 280 food commodities, categorized into various groups including vegetables, fruits, nuts, eggs, livestock, seafood, cereals, sugar, vegetable oils, stimulants, pulses, and ...
Antoine Coudard, Tom Szabo-Hemmings, Mona Honorine Delval, Sowmya Marriyapillai Ravisandiran, José Manuel Mogollón   +4 more
doaj   +1 more source

Enhancing Maritime Navigation with Mixed Reality: Assessing Remote Pilotage Concepts and Technologies by In Situ Testing

Journal of Marine Science and Engineering
In response to the evolving landscape of maritime operations, new technologies are on the horizon as mixed reality (MR), which shall enhance navigation safety and efficiency during remote assistance as, e.g., in the remote pilotage use case.
Arbresh Ujkani, Pascal Hohnrath, Robert Grundmann, Hans-Christoph Burmeister   +3 more
doaj   +1 more source