Results 151 to 160 of about 53,816 (309)

Dynamic Prognostic Nutritional Index With Circulating Tumor DNA Predicts Survival in Localized Pancreatic Ductal Adenocarcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives To evaluate the prognostic significance of baseline and longitudinal changes in prognostic nutritional index (PNI) in localized pancreatic ductal adenocarcinoma (PDAC) and to assess the complementary prognostic value of PNI with tumor burden measured by circulating tumor DNA (ctDNA).
Alex Horowitz, Claire Shen, Dominic J. Vitello, Madison Cox, Amy Wells, Krishay Sridalla, David J. Bentrem, Qiang Zhang, Ishan Roy, Akhil Chawla   +9 more
wiley   +1 more source

Targeting ligament boundaries rather than alignment boundaries in augmented‐reality‐assisted total knee arthroplasty ensures comparable gait patterns between operated and contralateral limbs

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Modern personalised total knee arthroplasty (TKA) techniques aim to mimic natural knee kinematics by focusing on soft‐tissue dynamics rather than static alignment. However, a consistent definition of the optimal ligamentous balance has not yet been established.
Michael Engl, Fjorela Qordja, Guido Bocchino, Giulio Maccauro, Sebastian Schaller, Andrea Giordano Salvi, Luca De Berardinis, Michele Paolo Festini Capello, Pieralberto Valpiana, Pier Francesco Indelli   +9 more
wiley   +1 more source

High‐Efficiency Graphene‐Silicon Slot‐Waveguide Microring Modulator at 1.5 and 2 µm Wavelength Bands

Laser &Photonics Reviews, EarlyView.
E/O modulators typically face a trade‐off between bandwidth and modulation efficiency. An integrated E/O modulator is presented that simultaneously achieves wideband, large bandwidth, and high modulation efficiency operation by embedding a partially overlapped double‐layer graphene on a compact silicon slot‐waveguide microring resonator.
Chao Luan, Deming Kong, Yong Liu, Yunhong Ding, Hao Hu   +4 more
wiley   +1 more source

Epitaxial Integration of III–V Membrane Photodetectors With Lateral p–i–n Junctions on the Silicon‐On‐Insulator Waveguide Platform

Laser &Photonics Reviews, EarlyView.
Epitaxial growth forms III–V membranes directly atop the silicon waveguide layer on SOI, while in‐plane in situ doping defines lateral p–i–n InP/InGaAs junctions in a single growth step. The membrane photodetectors achieve 50 Gb/s NRZ‐OOK operation.
Zhao Yan, Yifu Chen, Martin Ebert, Ka Ming Wong, Wenjie Wang, Tim Grieb, Florian F. Krause, Andreas Rosenauer, Graham T. Reed, David J. Thomson, Qiang Li   +10 more
wiley   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Application of Time‐Driven Activity‐Based Costing for Protocol‐Driven Adult Open Airway Reconstruction

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To describe a protocol‐driven approach to adult open airway reconstruction for benign airway stenosis and apply time‐driven activity‐based costing (TDABC) methodology to characterize resource utilization and cost drivers. Study Design Retrospective cohort study. Setting Tertiary academic medical center.
Andrew D. P. Prince, Fatameh Ramazani, Robbi A. Kupfer, Norman D. Hogikyan, Robert J. Morrison, Pratyusha Yalamanchi   +5 more
wiley   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Evaluating the Utility of RNAseq in Prenatal Diagnostics: Expression Profiles of Cultured Chorionic Villus and Amniotic Fluid Samples

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective While RNAseq has enhanced variant interpretation in postnatal cases, its potential in the prenatal setting remains underexplored. This study investigates the utility of RNAseq in prenatal diagnostics by analyzing the expression profiles of cultured chorionic villus samples (cCVS) and amniotic fluid (cAF) samples. Methods We performed
Maria C. Vladoiu, Sen Zhao, Roni Zemet, Christian M. Parobek, Jefferson Cruz Sinson, Stacy Tankersley, Ignatia B. Van den Veyver, Pengfei Liu   +7 more
wiley   +1 more source

Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants. [PDF]

Nat Med
Marston NA, Kany S, Melloni GEM, Jurgens SJ, Kamanu FK, Lai YP, Rämö JT, Raz I, Wiviott SD, Ellinor PT, Sabatine MS, Ruff CT.   +11 more
europepmc   +1 more source