Results 161 to 170 of about 53,816 (309)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Chronic Back Pain Increases Alzheimer's Disease Risk Independent of Gross Brain Structural Alterations: Genetic Evidence from Two Populations. [PDF]

J Pain Res
Huang FF, Sun Y, Hu Y, Chang JR, Zhou Z, Zheng DKY, Hsu CL, Samartzis D, Karppinen J, Al Zoubi FM, Fu SN, Wong AYL.   +11 more
europepmc   +1 more source

CMP Developer

, 2004
Since first published in 1998, the Enterprise JavaBeans technology has become a popular choice for the development of middleware systems. Even though its popularity, the technology is considered quite complex and rather difficult to master. The main contribution to its complexity is the part of the EJB that deals with persistence.
openaire   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer. [PDF]

Oncogenesis
Lin MY, Leu JD, Wu CY, Chen LC, Lee YJ.
europepmc   +1 more source

Alkynyl‐Bipyridine–Based Conjugated Microporous Polymer Anode for Lithium Storage

Small, EarlyView.
In this work, a sp‐ and sp2‐hybridized alkynyl‐bipyridine conjugated microporous polymer (Alk‐Bpy‐CMP) was designed and synthesized. This structure possesses a regular hexagonal pore and abundant active sites, and the energy storage mechanism was revealed.
Yuanyuan Zhang, Yuanyuan Liu, Xiaorui Wang, Xinyi Zhao, Manhua Peng, Hongwei Fan, Lin Zhang   +6 more
wiley   +1 more source

Topoclimas de agroecosistema de café para la adaptación al cambio climático en Cuba

Revista Cubana de Ciencias Forestales
Cuba implementa el Plan de Estado “Tarea Vida” para el enfrentamiento al cambio climático, lo que exige el conocimiento de las particularidades climáticas a escala local.
Loexis Rodriguez-Montoya, Arisleidys Peña de la Cruz, Ricado Delgado-Tellez, Carlos Alberto Miranda-Sierra, Yusmira Savón-Vaciano   +4 more
doaj  

Pediatric heart failure: A focus on low-income countries. [PDF]

World J Clin Pediatr
Ali SK.
europepmc   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, EarlyView.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Converting focused ultrasound-based boiling histotripsy into a systemic cancer vaccine using antigen-capturing microparticles. [PDF]

Theranostics
Singh A, Chandrasekar SV, Chamani F, Ashar H, Hartson S, Fiering S, Ranjan A.   +6 more
europepmc   +1 more source