Results 51 to 60 of about 91,518 (261)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Proceedings of The Tenth Annual Conference on Large Hadron Collider Physics — PoS(LHCP2022), 2023 Annual Conference on Large Hadron Collider Physics - LHCP2022 (10th. 2022. Online)
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The efects of heterosis of the sorghum hybrids F1 based on cytoplasmic male sterility
Зерновое хозяйство России, 2020 Currently, the development of highly productive sorghum hybrids with a high content of the main nutritional components in grain is of great relevance.
O. P. Kibalnik +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sistemas Gestores de Contenido (CMS). La solución ideal en la Web
Ingenius: Revista de Ciencia y Tecnología, 2008 Sistemas Gestores de Contenido (CMS).
Rodolfo Bojorque
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mathematics, 2019 A new approach to solve the compressible Navier-Stokes equations in cylindrical co-ordinates using Geometric Algebra is proposed. This work was recently initiated by corresponding author of this current work, and in contrast due to a now complete ...
Terry E. Moschandreou, Keith C. Afas
doaj +1 more source
Analysis of security CMS platforms by vulnerability scanners
Journal of Computer Sciences Institute, 2020 Subject of security the most popular CMS platforms has been undertaken in the following thesis. There were introduced fundamental informations about subject CMS platforms and vulnerability scanners utilised to research.
Patryk Zamościński, Grzegorz Kozieł
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source