Results 1 to 10 of about 68,640 (273)

Once-weekly TransCon CNP (navepegritide) in children with achondroplasia (ACcomplisH): a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-escalation trialResearch in context [PDF]

EClinicalMedicine, 2023
Summary: Background: TransCon CNP (navepegritide) is an investigational prodrug of C-type natriuretic peptide (CNP) designed to allow for continuous CNP exposure with once-weekly dosing.
Ravi Savarirayan, Daniel G. Hoernschemeyer, Merete Ljungberg, Yuri A. Zarate, Carlos A. Bacino, Michael B. Bober, Janet M. Legare, Wolfgang Högler, Teresa Quattrin, M. Jennifer Abuzzahab, Paul L. Hofman, Klane K. White, Nina S. Ma, Dirk Schnabel, Sérgio B. Sousa, Meng Mao, Alden Smith, Mukta Chakraborty, Adebola Giwa, Bent Winding, Birgitte Volck, Aimee D. Shu, Ciara McDonnell   +22 more
doaj   +2 more sources

Effect of C-Type Natriuretic Peptide (CNP) on Spermatozoa Maturation in Adult Rat Epididymis [PDF]

Current Issues in Molecular Biology, 2023
C-type natriuretic peptide (CNP) is highly expressed in male reproductive tissues, such as the epididymis. The aim of this study is to explore the role of CNP in the maturation of rat epididymal spermatozoa.
Hu Zhao, Yuejin Yu, Chunlei Mei, Tianyu Zhang, Yafei Kang, Na Li, Donghui Huang   +6 more
doaj   +2 more sources

CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2 [PDF]

Circulation Research, 2023
Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired.
Eleder Cachorro, Mario Günscht, Mario Schubert, Mirna S. Sadek, Johanna Siegert, Fabian Dutt, Carla Bauermeister, Susann Quickert, H. Berning, Felix Nowakowski, Simon Lämmle, Rebecca Firneburg, Xiaojing Luo, Stephan R. Künzel, Erik Klapproth, Peter Mirtschink, Manuel Mayr, Matthias Dewenter, Christiane Vettel, Jordi Heijman, Kristina Lorenz, Kaomei Guan, Ali El‐Armouche, Michael Wagner, Susanne Kämmerer   +24 more
openalex   +4 more sources

Vosoritide: a drug providing a promising avenue for the treatment of short stature in children with achondroplasia

Journal of Biochemical and Clinical Genetics, 2022
Not available [JBCGenetics 2022; 5(2.000): 059-060]
Amsal Qureshi, Areesha Moiz Alvi
doaj   +1 more source

Targeting the frontoparietal network using bifocal transcranial alternating current stimulation during a motor sequence learning task in healthy older adults

Brain Stimulation, 2022
Background: Healthy older adults show a decrease in motor performance and motor learning capacity as well as in working memory (WM) performance. WM has been suggested to be involved in motor learning processes, such as sequence learning.
L.R. Draaisma, M.J. Wessel, M. Moyne, T. Morishita, F.C. Hummel   +4 more
doaj   +1 more source

Salmonella chitosan nanoparticle vaccine administration is protective against Salmonella Enteritidis in broiler birds

PLoS ONE, 2021
Salmonella control strategies include vaccines that help reduce the spread of Salmonella in poultry flocks. In this study we evaluated the efficacy of administering a live Salmonella vaccine followed by a killed Salmonella chitosan nanoparticle (CNP ...
Keila Y. Acevedo-Villanueva, Sankar Renu, Revathi Shanmugasundaram, Gabriel O. Akerele, Renukaradhy J. Gourapura, Ramesh K. Selvaraj   +5 more
doaj   +2 more sources

Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect.

PLoS ONE, 2020
C-type natriuretic peptide (CNP) is a pivotal enhancer of endochondral bone growth and is expected to be a therapeutic reagent for impaired skeletal growth.
Yohei Ueda, Keisho Hirota, Ichiro Yamauchi, Takuro Hakata, Takafumi Yamashita, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki   +7 more
doaj   +2 more sources

Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

Scientific Reports, 2021
Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation.
Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel   +8 more
doaj   +1 more source

La 21ᵉ session du CNP [PDF]

Revue d'études palestiniennes, 1996
Ilan Halevi
openalex   +2 more sources

Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats. [PDF]

PLoS ONE, 2018
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a pivotal stimulator of endochondral bone growth. We recently developed CNP knockout (KO) rats that exhibit impaired skeletal growth with early growth ...
Keisho Hirota, Mayumi Furuya, Naomi Morozumi, Kazunori Yoshikiyo, Takafumi Yotsumoto, Toshimasa Jindo, Ryuichi Nakamura, Koichiro Murakami, Yohei Ueda, Takeshi Hanada, Hiroko Sade, Sayaka Yoshida, Kei Enomoto, Yugo Kanai, Ichiro Yamauchi, Takafumi Yamashita, Yoriko Ueda-Sakane, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki   +19 more
doaj   +1 more source