Results 161 to 170 of about 608,970 (315)

Case Report: Alectinib and CNS-directed therapy for primary or relapsed ALK-positive anaplastic large cell lymphoma with central nervous system involvement. [PDF]

Front Oncol
Mikalonytė M, Landsbergis V, Kevličius L, Černauskienė S, Davainis L, Žučenka A, Trociukas I, Pileckytė R, Davainienė B, Šlepikienė I, Ražanskienė G, Mickys U, Ražanskas J, Dementavičienė J, Stoškus M, Batiuškaitė R, Griškevičius L.   +16 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Clinical Characteristics, Treatment Patterns, and Prognosis of Central Nervous System Involvement in Multiple Myeloma: A Multicenter Retrospective Study From China. [PDF]

Cancer Med
Li W, Tian W, Ma J, Li L, Li Z, Liu J, Gao G, Xi Z, Zhang L, Zhang W, Duan L, Geng H, Meng J, Zhu H, Chen W, Gao W.   +15 more
europepmc   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Isolated Hypoglossal Nerve Schwannoma: An Uncommon Presentation of Schwannoma [PDF]

Journal of Clinical and Diagnostic Research, 2015
Pokhraj Prakashchandra Suthar, Kewal Arunkumar Mistry, Patel Rajan, Patel Ankit, Chetan Mehta   +4 more
doaj   +1 more source

Retinoblastoma with spinal cord metastasis: When an eye tumor bites the cord!

Indian Journal of Ophthalmology. Case Reports, 2021
Pritam Singha Roy, Usha Singh, Sameeksha Tadepalli, Chirag Kamal Ahuja, Deepak Bansal   +4 more
doaj   +1 more source

Clinical outcomes of CD3xCD20 bispecific antibodies in patients with central nervous system involvement by lymphoma. [PDF]

Blood Cancer J
Chohan KL, Welkie RL, Godfrey J, Bair S, Falchi L, Kamdar M, Major A, Dixon W, Crombie J, Merryman R, Godbole S, Salles G, Farahat O, Ayers A, Chauhan A, Herrera A, Shouse G, Ahmed S, Sawalha Y.   +18 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Characterizing treatment initiation with central nervous system-active polypharmacy among adults with dementia. [PDF]

Alzheimers Dement
Maust DT, Davis RC, Strominger J, Marcus SC, Kim HM, Caverly T, Blow FC, Wallner LP, Krein S, Vordenberg SE.   +9 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source