Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient [PDF]
, 2018 As in other brain tumors, multiple recurrences after complete resection and irradiation of supratentorial ependymoma are common and frequently result in patient death.
Dahiya, Sonika +7 more
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Histopathological Study of Central Nervous System Lesions
Medical Journal of Dr. D.Y. Patil VidyapeethBackground: Central nervous system (CNS) tumors are distinct due to their origin from specialized tissues and the unique anatomical features of the CNS.
Madhur Y. Modi +3 more
doaj +1 more source
iScienceSummary: Recognizing individuals with Genetic tumor syndromes (GTS) in the primary central nervous system (CNS) tumors is crucial for optimizing proper genetic counseling and improving therapeutics and clinical care.
Chuanwei Wang +8 more
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Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids
, 2018 Standard treatment regimens consisting of surgery, radiation and chemotherapy have proven ineffective for the treatment of high-grade gliomas such as glioblastoma multiforme (GBM).
Singh, Karanjit
core +1 more source
Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]
, 2020 Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak +4 more
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Total Number of Alterations in Liquid Biopsies Is an Independent Predictor of Survival in Patients With Advanced Cancers. [PDF]
, 2020 PurposeStudies have demonstrated an association between quantity of circulating tumor DNA (ctDNA) and poorer survival. We investigated the relationship between percent ctDNA (%ctDNA), total number of ctDNA alterations, and overall survival (OS) in liquid
Goodman, Aaron +4 more
core
Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. [PDF]
, 2019 Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors ...
Chen, Irvin SY +18 more
core +1 more source
Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements. [PDF]
, 2009 The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation.
Ho, Allen L +4 more
core +3 more sources
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
core +1 more source
Central Nervous System Tumors in Guilan, Iran: Epidemiological Features Over 10 Years
Caspian Journal of Neurological Sciences, 2015 Background: Tumors of the central nervous system (CNS) are a heterogeneous group of neoplasms with different prevalence in different sex and age groups and various parts of CNS.
Kourosh Askari +4 more
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