Results 41 to 50 of about 75,040 (259)

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits [PDF]

, 2017
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 ...
Martin D Tobin (7795649), et al (2618167), Nick Shrine (220391), Louise V Wain (7795652)   +3 more
core   +3 more sources

Classification of homologous genes (CNV/non-CNV) into the curated gene classes.

, 2013
Classification of homologous genes (CNV/non-CNV) into the curated gene classes.
Kyriacos Felekkis (491527), Harsh Dweep (104858), Constantinos Deltas (333799), Konstantinos Voskarides (333789), George D. Georgiou (491526), Norbert Gretz (14081)   +5 more
core   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Anti-vascular endothelial growth factor therapy for posterior segment diseases: Progress, challenges, and the road ahead

Indian Journal of Ophthalmology
The emergence of anti-vascular endothelial growth factor (anti-VEGF) therapy has marked a paradigm shift in the treatment of retinal and choroidal vascular diseases.
Chitaranjan Mishra, Nabatika Mohanty, Somy Purohit, Udayasree Orugonda, Vaishnavi Patil   +4 more
doaj   +1 more source

In vivo evaluation of laser-induced choroidal neovascularization in rats simultaneously using optical coherence tomography and photoacoustic microscopy

Journal of Innovative Optical Health Sciences, 2021
Determination of the precise location and the degree of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment.
Fengxian Du, Lei Gao, Lin Li, Qian Li, Fenghua Wang, Chuanqing Zhou, Cuixia Dai   +6 more
doaj   +1 more source

Overview of module subtype and size in CNV-ICC-TRN.

, 2014
In both A and B figures, blue color represents CNV-gene-only enriched module, green color represents CNV-TF-only regulated module, red color represents both CNV-TF regulated and CNV-gene enriched module.
Wei Li (7081), Lu Xie (55571), Chao Li (145513), Yuannv Zhang (385506), Ling Li (38566), Jing Li (10611), Baofeng Lian (572694), Yixue Li (18673), Xianghuo He (123411)   +8 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

RPE disruption and hyper-transmission are early signs of secondary CNV with punctate inner choroidopathy in structure-OCT

BMC Ophthalmology, 2021
Purpose To study whether retinal pigment epithelium (RPE) disruption and choroidal hyper-transmission on spectral-domain optical coherence tomography (SD-OCT) are signs of inflammatory neovascularization (CNV) in punctate inner choroidopathy (PIC ...
Yanru Chen, Qian Chen, Xiaoxin Li, Minghan Li   +3 more
doaj   +1 more source

Combined Karyotyping, Copy Number Variation Sequencing, and Whole Exome Sequencing in the Prenatal Diagnosis of Congenital Heart Disease: Detection Rates and Phenotypic Associations [PDF]

J Clin Lab Anal
This study combined karyotyping, copy number variation sequencing, and whole‐exome sequencing to assess the value of genetic testing in the prenatal diagnosis of congenital heart disease (CHD) and to evaluate the relationship between genetic variants and prenatal phenotypes.
Xie J, Huang Y, Yao X, Zhang L, Zhou Y, Wang W, Zhang J, Ge Y.   +7 more
europepmc   +2 more sources