Results 51 to 60 of about 67,701 (309)
Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study. [PDF]
PLoS Computational Biology, 2012 Choroidal neovascularization (CNV) of the macular area of the retina is the major cause of severe vision loss in adults. In CNV, after choriocapillaries initially penetrate Bruch's membrane (BrM), invading vessels may regress or expand (CNV initiation ...
Abbas Shirinifard +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Post-filter CNV counts and relative CNV frequency. [PDF]
, 2014 The CNV counts shown here represent the 43,560 candidate CNVs that remain after applying the Post-filter. The first column shows a specific CNV count. The second set of columns show the number of control and case individuals observed at each given CNV ...
Rakesh Chettier (73475) +2 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits
Scientific Reports, 2023 This study aimed to demonstrate longitudinal multimodal imaging of laser photocoagulation-induced choroidal neovascularization (CNV) in pigmented rabbits. Six Dutch Belted pigmented rabbits were treated with 12 laser lesions in each eye at a power of 300
Van Phuc Nguyen +5 more
doaj +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Unambiguously phased CNV regions in families. [PDF]
, 2015 Percentage of CNV regions in HapMap YRI and EGCUT families where PiCNV was automatically able to unambiguously determine the underlying normal and CNV-carrying haplotypes in parents and follow their transmission in offspring.
Priit Palta (116414) +9 more
core +1 more source
Indian Journal of OphthalmologyThe emergence of anti-vascular endothelial growth factor (anti-VEGF) therapy has marked a paradigm shift in the treatment of retinal and choroidal vascular diseases.
Chitaranjan Mishra +4 more
doaj +1 more source
Factors associated with the recurrence of choroidal neovascularization in pathologic myopia
Frontiers in Medicine, 2022 PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing +3 more
doaj +1 more source
Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source