Results 51 to 60 of about 75,040 (259)
Mapping of SPase cleavage sites in wild-type or mutated versions of Rasp2 S-cNV-H6.
, 2016 (A) Amino acid alignment of the C-terminal region of the NTB domain of relevant mutants of Rasp2 (as in Fig 3A). Mutated aa are underlined. In the case of the G578stop and A585stop mutants, stop codons were introduced at the indicated position resulting ...
Hélène Sanfaçon (286430) +2 more
core +1 more source
Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
, 1986 本工作改变了CNV的常规模式:增加一次警告信号,将按键反应改为分辨以排除CNV中的运动因素,结果发现了二级CNV增大现象和解脱波。据此对现有诸CNV心理因素假说进行了讨论,认为CNV中的心理因素不是单一性的 ...
魏景汉, 尔朱光
core +1 more source
Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia
Journal of Ophthalmology, 2015 Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods.
Wei Chen +6 more
doaj +1 more source
eLife, 2020 NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis ...
Jakob Malsy +4 more
doaj +1 more source
Distribution of known miRNA within CNV and non-CNV genes among 8 different species.
, 2013 Distribution of known miRNA within CNV and non-CNV genes among 8 different species.
Kyriacos Felekkis (491527) +5 more
core +1 more source
Advanced Science, EarlyView.Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu +12 more
wiley +1 more source
PLoS ONE, 2019 PurposeVessel maturation is considered to proceed by pruning branches resulting in less branching vessels. This study investigated the vessel junction densities of type 1 and type 2 choroidal neovascularizations (CNVs) using optical coherence tomography ...
Yuyako Nakano +7 more
doaj +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
, 2014 CNV area size was evaluated on flatmount on day 7. (A) CNV induced by laser in the mice expressing different levels of GPx4. Scale bar, 500 µm.
Hirotaka Imai (241758) +4 more
core +1 more source