Results 71 to 80 of about 67,701 (309)
The relationship between developmental changes of contingent negative variation (CNV) resolution and the scores of 4 cognitive tests [PDF]
, 2003 本研究の目的は，随伴性陰性変動（CNV）の解消過程の個体発達に伴う変化と視覚短期記憶，聴覚短期記憶，視空間構成能力，実行機能などの認知発達との関係をとらえ，CNV解消課程が，どのような認知発達と関係するか検証することである．また，CNV解消課程と認知機能発達との関係が，P300と認知機能発達との関係とどう異なるかについても見た． ７～24歳（平均14歳２ヶ月±５歳７ケ月）の15名を対象に，CNV，CNV解消課程，P300を測定し，同時に実施した４種の認知検査（WISC-Ⅲの「数唱」，「積木模様」，K ...
船瀬, 広三 +2 more
core
Advanced Science, EarlyView.Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan +11 more
wiley +1 more source
White horses – non-coding sequences drive premature hair greying and predisposition to melanoma
Upsala Journal of Medical SciencesThe Grey allele in horses is causing premature hair greying and susceptibility to melanoma. The causal mutation is a 4.6 kb tandem duplication in intron 6 of the Syntaxin 17 gene. A recent study demonstrated that the most common allele at the Grey locus (
Leif Andersson
doaj +1 more source
Advanced Science, EarlyView.The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui +9 more
wiley +1 more source
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition [PDF]
, 2020 Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders.
ENIGMA-CNV Working Group
core
CNV discovery in the Thai population. [PDF]
, 2014 a) Diagram showing Thai CNV discovery workflow; b) % overlap proportion of CNVs identified by both CNV Workshop and PennCNV based on CNV size (bp). The regions shaded in red correspond to CNVs exclusively discovered by CNV Workshop, while regions shaded ...
Wallaya Jongjaroenprasert (614574) +12 more
core +1 more source
Genetic architecture of reciprocal CNVs [PDF]
Current Opinion in Genetics & Development, 2013 Copy number variants (CNVs) represent a frequent type of lesion in human genetic disorders that typically affects numerous genes simultaneously. This has raised the challenge of understanding which genes within a CNV drive clinical phenotypes. Although CNVs can arise by multiple mechanisms, a subset is driven by local genomic architecture permissive to
Christelle, Golzio, Nicholas, Katsanis
openaire +2 more sources
Advanced Science, EarlyView.Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu +13 more
wiley +1 more source
, 1986 本工作改变了CNV的常规模式:增加一次警告信号,将按键反应改为分辨以排除CNV中的运动因素,结果发现了二级CNV增大现象和解脱波。据此对现有诸CNV心理因素假说进行了讨论,认为CNV中的心理因素不是单一性的 ...
魏景汉, 尔朱光
core
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source