Results 71 to 80 of about 114,077 (305)
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia
Journal of Ophthalmology, 2015 Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods.
Wei Chen +6 more
doaj +1 more source
eLife, 2020 NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis ...
Jakob Malsy +4 more
doaj +1 more source
Journal of Innovative Optical Health Sciences, 2021 Determination of the precise location and the degree of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment.
Fengxian Du +6 more
doaj +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
PLoS ONE, 2019 PurposeVessel maturation is considered to proceed by pruning branches resulting in less branching vessels. This study investigated the vessel junction densities of type 1 and type 2 choroidal neovascularizations (CNVs) using optical coherence tomography ...
Yuyako Nakano +7 more
doaj +1 more source
A hierarchical Bayesian model for inference of copy number variants and their association to gene expression [PDF]
, 2014 A number of statistical models have been successfully developed for the analysis of high-throughput data from a single source, but few methods are available for integrating data from different sources.
Cassese, Alberto +4 more
core +2 more sources
Genetic architecture of reciprocal CNVs [PDF]
Current Opinion in Genetics & Development, 2013 Copy number variants (CNVs) represent a frequent type of lesion in human genetic disorders that typically affects numerous genes simultaneously. This has raised the challenge of understanding which genes within a CNV drive clinical phenotypes. Although CNVs can arise by multiple mechanisms, a subset is driven by local genomic architecture permissive to
Christelle, Golzio, Nicholas, Katsanis
openaire +2 more sources
Advanced Science, EarlyView.To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu +6 more
wiley +1 more source
Skyrmion robustness in non-centrosymmetric magnets with axial symmetry: The role of anisotropy and tilted magnetic fields [PDF]
, 2017 We investigate the stability of N\'eel skyrmions against tilted magnetic fields, in polar magnets with uniaxial anisotropy ranging from easy-plane to easy-axis type.
Kézsmárki, I., Leonov, A. O.
core +2 more sources