Results 71 to 80 of about 5,986,469 (304)

Long-term response of oceanic carbon uptake to global warming via physical and biological pumps [PDF]

Biogeosciences, 2018
Global warming is expected to significantly decrease oceanic carbon uptake and therefore increase atmospheric CO2 and global warming. The primary reasons given in previous studies for such changes in the oceanic carbon uptake are the solubility ...
A. Yamamoto, A. Yamamoto, A. Abe-Ouchi, A. Abe-Ouchi, Y. Yamanaka   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of Water Masses and Circulation on the Surface Water Partial Pressure of Carbon Dioxide in Summer in Eastern Beibu Gulf, China

Journal of Marine Science and Engineering, 2022
A gulf is a typical ecological zone where carbon cycle is jointly affected by complex environmental factors and strong human activities, and the Beibu Gulf has complex water masses and circulation structures.
Yu Ma, Tuanjie Li, Huayong Xia, Ruixiang Li, Yonggang Cao, Huaming Shi, Xin Xu, Jinshang Zhang, Weijie Zhang, Xibao Su   +9 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Natural genetic recombination between co-circulating heterotypic enteroviruses

Journal of General Virology, 2002
Natural recombination in poliovirus is a frequent phenomenon. In practice, whenever different genotypes have the opportunity to infect the same individual, a high proportion of viruses with recombinant genomes are excreted. To determine whether enteroviruses other than poliovirus can naturally produce viable virions with recombinant genomes, we studied
Gabriela, Oprisan, Mariana, Combiescu, Sophie, Guillot, Valerie, Caro, Andrei, Combiescu, Francis, Delpeyroux, Radu, Crainic   +6 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Analytical Solutions for Steady-State Multiwell Aquifer Tests in Rectangular Aquifers by Using Double Fourier Transform: A Case Study in the Ordos Plateau, China

Geofluids, 2020
Straightforward solutions have long been expected for the analysis of multiwell aquifer tests. In this paper, we derive series analytical solutions of steady-state groundwater flow in a rectangular-shaped aquifer with pumping/injection wells for both ...
Jun-Zhi Wang, Xu-Sheng Wang, Qing-Bo Li, Wei-Feng Wan   +3 more
doaj   +1 more source