Results 111 to 120 of about 421,786 (290)
Value Co-Creation with Suppliers [PDF]
The growing specialization of firms and the reinforcement of vertical disintegration have led to an increasing reliance on purchasing and supply management.
Carlos Brito, Catarina Roseira
core
Value proposition as a framework for value co-creation in crowd-funding ecosystem [PDF]
, 2015 The present paper suggests that crowd-funding in the arts and cultural sector occurs within a complex service ecosystem, where six categories of value propositions frame eight value co-creation processes, namely through ideation, evaluation, design ...
Kelleher, Carol +2 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Role of Empathetic Company Philosophy and Advanced Technologies in Shaping Job Attitudes
Business Systems ResearchAlthough the literature has assessed various factors underlying employee attitudes, knowledge of company philosophy and advanced technology is lacking, especially in the context of the major drivers of job satisfaction and turnover intentions.
Koizumi Masaki, Kato Takumi
doaj +1 more source
Co-Creation dengan Komunitas Bike To Work Indonesia sebagai Strategi Komunikasi Pemasaran Polygon [PDF]
, 2014 Konsumen yang aktif berkomunitas memiliki kecenderungan untuk secara aktif mencari informasi, membagikannya, serta saling mempengaruhi antar anggota komunitas.
Ardianto, E. (Eka) +4 more
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Living labs for in-situ open innovation: from idea to product validation and beyond [PDF]
, 2014 In this paper we present the Living Lab methodology as an overall framework for in-situ open innovation involving the end-user as equal participant in the innovation process.
Baccarne, Bastiaan +6 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source