Results 111 to 120 of about 6,704,341 (266)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Co-Creation and bridging theory-method divides

, 2020
In this chapter, we explore the possibilities and challenges posed by Co-Creation as a knowledge practice that is more than a ‘novel method’ for addressing urban inequality, disadvantage and territorial stigmatisation. CoCreation is informed by a diverse
Fullagar, S, Depper, A
core  

Integrated transcriptomic analysis reveals miRNA-hub mRNA-TF interactions and key regulatory targets in STEC infected intestinal epithelial cells

Frontiers in Cellular and Infection Microbiology
BackgroundShiga toxin-producing Escherichia coli (STEC) is a leading foodborne pathogen responsible for hemolytic uremic syndrome (HUS). This pathogen poses a severe threat to global public health.
Baili Zheng, Xiaoyue Su, Yongchao Li, Qiang Fu, Xuelian Ma, Bao Zhou, Bing Peng, Rulong Chen, Yingyu Liu   +8 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Retaining Ways of Co-Creation.

, 2023
The design space of future mobility services is considered a wicked problem, as many stakeholders from the public and private sectors need to collaborate to create sustainable future services. Recent years have shown a growing interest in utilizing urban living labs (ULL) and similar quadruple helix approaches toward addressing wicked design challenges.
Ebbesson, Esbjörn, Fors, Vaike
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Co-production and co-creation using self-service technology: the application of service-dominant logic

, 2008
Research on how customers engage in the co-creation processes envisaged by the Servicedominant logic paradigm is currently limited and even less work has been published on frameworks for organizations to manage the co-creation process.
Hilton, T., Hughes, T.
core  

Local effects of non-pharmaceutical interventions on mitigation of COVID-19 spread through decreased human mobilities in Japan: a prefecture-level mediation analysis

Scientific Reports
To control the COVID-19 epidemic, the Japanese government and the local governments have repeatedly implemented non-pharmaceutical interventions (NPIs) throughout 2020–2022.
Shohei Nagata, Yuta Takahashi, Hiroki M. Adachi, Glen D. Johnson, Tomoki Nakaya   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source